Abstract
We have identified two related series of dibenzazepine and dibenzoxazepine sodium channel blockers, which showed good potency on Nav1.7 in FLIPR-based and electrophysiological functional assays.
Original language | English |
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Pages (from-to) | 43-47 |
Number of pages | 5 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 25 |
Issue number | 1 |
DOIs | |
State | Published - 1 Jan 2015 |
Externally published | Yes |
Keywords
- Dibenzazepine
- Dibenzoxazepine
- Na<inf>v</inf>1.7
- Neuropathic pain
- Sodium channel