Dibenzazepines and dibenzoxazepines as sodium channel blockers

Stephen M. Lynch, Laykea Tafesse, Kevin Carlin, Parijat Ghatak, Donald J. Kyle

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


We have identified two related series of dibenzazepine and dibenzoxazepine sodium channel blockers, which showed good potency on Nav1.7 in FLIPR-based and electrophysiological functional assays.

Original languageEnglish
Pages (from-to)43-47
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number1
StatePublished - 1 Jan 2015
Externally publishedYes


  • Dibenzazepine
  • Dibenzoxazepine
  • Na<inf>v</inf>1.7
  • Neuropathic pain
  • Sodium channel


Dive into the research topics of 'Dibenzazepines and dibenzoxazepines as sodium channel blockers'. Together they form a unique fingerprint.

Cite this