Dibenzazepines and dibenzoxazepines as sodium channel blockers

Stephen M. Lynch, Laykea Tafesse, Kevin Carlin, Parijat Ghatak, Donald J. Kyle

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

We have identified two related series of dibenzazepine and dibenzoxazepine sodium channel blockers, which showed good potency on Nav1.7 in FLIPR-based and electrophysiological functional assays.

Original languageEnglish
Pages (from-to)43-47
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume25
Issue number1
DOIs
StatePublished - 1 Jan 2015
Externally publishedYes

Keywords

  • Dibenzazepine
  • Dibenzoxazepine
  • Na<inf>v</inf>1.7
  • Neuropathic pain
  • Sodium channel

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