Abstract
A murine monoclonal antibody (MAb) with human CD4 specificity was tested for the ability to inhibit primary human immunodeficiency virus type 1 (HIV- 1) isolates clades A through E. Human peripheral blood mononuclear cells (PBMC) were used as target cells for infectivity. The HIV-1 primary isolates were examined for the capacity to infect PBMC targets in the presence or absence of the anti-CD4 MAb, designated P1. P1 broadly inhibited clade A, C, D, and E isolates, based on a reduction of HIV-1 p24 antigen concentrations compared with untreated controls. Little to no virus-inhibiting activity was observed with a primary HIV-1 clade B isolate, designated BZ167. Additionally, a second primary clade B isolate was efficiently inhibited from infecting PBMC targets by P1. The data indicate that P1 exhibits group- specific inhibiting activity against non-clade B primary HIV-1 isolates in vitro.
Original language | English |
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Pages (from-to) | 1727-1729 |
Number of pages | 3 |
Journal | Journal of Infectious Diseases |
Volume | 177 |
Issue number | 6 |
DOIs | |
State | Published - 1998 |