Cranberries improve postprandial glucose excursions in type 2 diabetes

Jace Schell, Nancy M. Betts, Megan Foster, R. Hal Scofield, Arpita Basu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Recent research supports a favorable role of cranberries on cardiometabolic health. Postprandial metabolism, especially hyperglycemia, has been shown to be an independent cardiovascular risk and few clinical studies have reported the role of berries in improving postprandial dysmetabolism. We investigated the postprandial effects of dried cranberries following a high-fat breakfast challenge in obese participants with type 2 diabetes (T2DM), in a randomized crossover trial. Blood draw and vascular measurements were conducted at fasting, 1, 2 and 4 hours (h), following the consumption of a fast-food style high-fat breakfast (70 g fat, 974 kcal) with or without cranberries (40 g). Analyses of our data (n = 25; BMI (kg m-2) (mean ± s.d.) = 39.5 ± 6.5; age (years) = 56 ± 6) revealed that postprandial increases in glucose were significantly lower in the cranberry vs. control at 2 & 4 h (p < 0.05). No significant differences were noted in insulin, insulin resistance evaluated by homeostasis model assessment, lipid profiles and blood pressure between the cranberry and control groups. Among the biomarkers of inflammation and oxidation, postprandial serum interleukin-18 and malondialdehyde were significantly lower at 4 h, and serum total nitrite was higher at 2 h in the cranberry vs. control group (all p < 0.05). No effects were noted on C-reactive protein or interlukin-6. Overall, dietary cranberries had notable effects in improving high-fat breakfast induced postprandial glucose and selected biomarkers of inflammation and oxidation in participants with T2DM. These findings provide evidence that adding whole cranberries to a high-fat meal may improve postprandial blood glucose management and warrant further investigation.

Original languageEnglish
Pages (from-to)3083-3090
Number of pages8
JournalFood and Function
Volume8
Issue number9
DOIs
StatePublished - 1 Sep 2017
Externally publishedYes

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Vaccinium macrocarpon
cranberries
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
Glucose
glucose
Fats
Breakfast
breakfast
lipids
blood serum
biomarkers
inflammation
Biomarkers
oxidation
Inflammation
Fast Foods
interleukin-18
fast foods
Control Groups

Cite this

Schell, Jace ; Betts, Nancy M. ; Foster, Megan ; Scofield, R. Hal ; Basu, Arpita. / Cranberries improve postprandial glucose excursions in type 2 diabetes. In: Food and Function. 2017 ; Vol. 8, No. 9. pp. 3083-3090.
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Schell, J, Betts, NM, Foster, M, Scofield, RH & Basu, A 2017, 'Cranberries improve postprandial glucose excursions in type 2 diabetes', Food and Function, vol. 8, no. 9, pp. 3083-3090. https://doi.org/10.1039/c7fo00900c

Cranberries improve postprandial glucose excursions in type 2 diabetes. / Schell, Jace; Betts, Nancy M.; Foster, Megan; Scofield, R. Hal; Basu, Arpita.

In: Food and Function, Vol. 8, No. 9, 01.09.2017, p. 3083-3090.

Research output: Contribution to journalArticle

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AU - Schell, Jace

AU - Betts, Nancy M.

AU - Foster, Megan

AU - Scofield, R. Hal

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