Correspondence Between Perceived Pubertal Development and Hormone Levels in 9-10 Year-Olds From the Adolescent Brain Cognitive Development Study

Megan M. Herting; Kristina A. Uban; Marybel Robledo Gonzalez; Fiona C. Baker; Eric C. Kan; Wesley K. Thompson; Douglas A. Granger; Matthew D. Albaugh; Andrey P. Anokhin; Kara S. Bagot; Marie T. Banich; Deanna M. Barch; Arielle Baskin-Sommers; Florence J. Breslin; B. J. Casey; Bader Chaarani; Linda Chang; Duncan B. Clark; Christine C. Cloak; R. Todd Constable; Linda B. Cottler; Rada K. Dagher; Mirella Dapretto; Anthony S. Dick; Nico Dosenbach; Gayathri J. Dowling; Julie A. Dumas; Sarah Edwards; Thomas Ernst; Damien A. Fair; Sarah W. Feldstein-Ewing; Edward G. Freedman; Bernard F. Fuemmeler; Hugh Garavan; Dylan G. Gee; Jay N. Giedd; Paul E.A. Glaser; Aimee Goldstone; Kevin M. Gray; Samuel W. Hawes; Andrew C. Heath; Mary M. Heitzeg; John K. Hewitt; Charles J. Heyser; Elizabeth A. Hoffman; Rebekah S. Huber; Marilyn A. Huestis; Luke W. Hyde; M. Alejandra Infante; Masha Y. Ivanova; Joanna Jacobus; Terry L. Jernigan; Nicole R. Karcher; Angela R. Laird; Kimberly H. LeBlanc; Krista Lisdahl; Monica Luciana; Beatriz Luna; Hermine H. Maes; Andrew T. Marshall; Michael J. Mason; Erin C. McGlade; Amanda S. Morris; Bonnie J. Nagel; Gretchen N. Neigh; Clare E. Palmer; Martin P. Paulus; Alexandra S. Potter; Leon I. Puttler; Nishadi Rajapakse; Kristina Rapuano; Gloria Reeves; Perry F. Renshaw; Claudiu Schirda; Kenneth J. Sher; Chandni Sheth; Paul D. Shilling; Lindsay M. Squeglia; Matthew T. Sutherland; Susan F. Tapert; Rachel L. Tomko; Deborah Yurgelun-Todd; Natasha E. Wade; Susan R.B. Weiss; Robert A. Zucker; Elizabeth R. Sowell

doi:10.3389/fendo.2020.549928

Correspondence Between Perceived Pubertal Development and Hormone Levels in 9-10 Year-Olds From the Adolescent Brain Cognitive Development Study

Megan M. Herting, Kristina A. Uban, Marybel Robledo Gonzalez, Fiona C. Baker, Eric C. Kan, Wesley K. Thompson, Douglas A. Granger, Matthew D. Albaugh, Andrey P. Anokhin, Kara S. Bagot, Marie T. Banich, Deanna M. Barch, Arielle Baskin-Sommers, Florence J. Breslin, B. J. Casey, Bader Chaarani, Linda Chang, Duncan B. Clark, Christine C. Cloak, R. Todd ConstableLinda B. Cottler, Rada K. Dagher, Mirella Dapretto, Anthony S. Dick, Nico Dosenbach, Gayathri J. Dowling, Julie A. Dumas, Sarah Edwards, Thomas Ernst, Damien A. Fair, Sarah W. Feldstein-Ewing, Edward G. Freedman, Bernard F. Fuemmeler, Hugh Garavan, Dylan G. Gee, Jay N. Giedd, Paul E.A. Glaser, Aimee Goldstone, Kevin M. Gray, Samuel W. Hawes, Andrew C. Heath, Mary M. Heitzeg, John K. Hewitt, Charles J. Heyser, Elizabeth A. Hoffman, Rebekah S. Huber, Marilyn A. Huestis, Luke W. Hyde, M. Alejandra Infante, Masha Y. Ivanova, Joanna Jacobus, Terry L. Jernigan, Nicole R. Karcher, Angela R. Laird, Kimberly H. LeBlanc, Krista Lisdahl, Monica Luciana, Beatriz Luna, Hermine H. Maes, Andrew T. Marshall, Michael J. Mason, Erin C. McGlade, Amanda S. Morris, Bonnie J. Nagel, Gretchen N. Neigh, Clare E. Palmer, Martin P. Paulus, Alexandra S. Potter, Leon I. Puttler, Nishadi Rajapakse, Kristina Rapuano, Gloria Reeves, Perry F. Renshaw, Claudiu Schirda, Kenneth J. Sher, Chandni Sheth, Paul D. Shilling, Lindsay M. Squeglia, Matthew T. Sutherland, Susan F. Tapert, Rachel L. Tomko, Deborah Yurgelun-Todd, Natasha E. Wade, Susan R.B. Weiss, Robert A. Zucker, Elizabeth R. Sowell

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Abstract

Aim: To examine individual variability between perceived physical features and hormones of pubertal maturation in 9–10-year-old children as a function of sociodemographic characteristics. Methods: Cross-sectional metrics of puberty were utilized from the baseline assessment of the Adolescent Brain Cognitive Development (ABCD) Study—a multi-site sample of 9–10 year-olds (n = 11,875)—and included perceived physical features via the pubertal development scale (PDS) and child salivary hormone levels (dehydroepiandrosterone and testosterone in all, and estradiol in females). Multi-level models examined the relationships among sociodemographic measures, physical features, and hormone levels. A group factor analysis (GFA) was implemented to extract latent variables of pubertal maturation that integrated both measures of perceived physical features and hormone levels. Results: PDS summary scores indicated more males (70%) than females (31%) were prepubertal. Perceived physical features and hormone levels were significantly associated with child’s weight status and income, such that more mature scores were observed among children that were overweight/obese or from households with low-income. Results from the GFA identified two latent factors that described individual differences in pubertal maturation among both females and males, with factor 1 driven by higher hormone levels, and factor 2 driven by perceived physical maturation. The correspondence between latent factor 1 scores (hormones) and latent factor 2 scores (perceived physical maturation) revealed synchronous and asynchronous relationships between hormones and concomitant physical features in this large young adolescent sample. Conclusions: Sociodemographic measures were associated with both objective hormone and self-report physical measures of pubertal maturation in a large, diverse sample of 9–10 year-olds. The latent variables of pubertal maturation described a complex interplay between perceived physical changes and hormone levels that hallmark sexual maturation, which future studies can examine in relation to trajectories of brain maturation, risk/resilience to substance use, and other mental health outcomes.

Original language	English
Article number	549928
Journal	Frontiers in Endocrinology
Volume	11
DOIs	https://doi.org/10.3389/fendo.2020.549928
State	Published - 18 Feb 2021

Keywords

adolescent brain cognitive development
dehydroepiandrosterone
estradiol
pubertal development scale
puberty
salivary hormones
testosterone

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10.3389/fendo.2020.549928

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Herting, M. M., Uban, K. A., Gonzalez, M. R., Baker, F. C., Kan, E. C., Thompson, W. K., Granger, D. A., Albaugh, M. D., Anokhin, A. P., Bagot, K. S., Banich, M. T., Barch, D. M., Baskin-Sommers, A., Breslin, F. J., Casey, B. J., Chaarani, B., Chang, L., Clark, D. B., Cloak, C. C., ... Sowell, E. R. (2021). Correspondence Between Perceived Pubertal Development and Hormone Levels in 9-10 Year-Olds From the Adolescent Brain Cognitive Development Study. Frontiers in Endocrinology, 11, Article 549928. https://doi.org/10.3389/fendo.2020.549928

@article{12ac05539a4f498ba584c89e0d17a0f2,

title = "Correspondence Between Perceived Pubertal Development and Hormone Levels in 9-10 Year-Olds From the Adolescent Brain Cognitive Development Study",

abstract = "Aim: To examine individual variability between perceived physical features and hormones of pubertal maturation in 9–10-year-old children as a function of sociodemographic characteristics. Methods: Cross-sectional metrics of puberty were utilized from the baseline assessment of the Adolescent Brain Cognitive Development (ABCD) Study—a multi-site sample of 9–10 year-olds (n = 11,875)—and included perceived physical features via the pubertal development scale (PDS) and child salivary hormone levels (dehydroepiandrosterone and testosterone in all, and estradiol in females). Multi-level models examined the relationships among sociodemographic measures, physical features, and hormone levels. A group factor analysis (GFA) was implemented to extract latent variables of pubertal maturation that integrated both measures of perceived physical features and hormone levels. Results: PDS summary scores indicated more males (70\%) than females (31\%) were prepubertal. Perceived physical features and hormone levels were significantly associated with child{\textquoteright}s weight status and income, such that more mature scores were observed among children that were overweight/obese or from households with low-income. Results from the GFA identified two latent factors that described individual differences in pubertal maturation among both females and males, with factor 1 driven by higher hormone levels, and factor 2 driven by perceived physical maturation. The correspondence between latent factor 1 scores (hormones) and latent factor 2 scores (perceived physical maturation) revealed synchronous and asynchronous relationships between hormones and concomitant physical features in this large young adolescent sample. Conclusions: Sociodemographic measures were associated with both objective hormone and self-report physical measures of pubertal maturation in a large, diverse sample of 9–10 year-olds. The latent variables of pubertal maturation described a complex interplay between perceived physical changes and hormone levels that hallmark sexual maturation, which future studies can examine in relation to trajectories of brain maturation, risk/resilience to substance use, and other mental health outcomes.",

keywords = "adolescent brain cognitive development, dehydroepiandrosterone, estradiol, pubertal development scale, puberty, salivary hormones, testosterone",

author = "Herting, \{Megan M.\} and Uban, \{Kristina A.\} and Gonzalez, \{Marybel Robledo\} and Baker, \{Fiona C.\} and Kan, \{Eric C.\} and Thompson, \{Wesley K.\} and Granger, \{Douglas A.\} and Albaugh, \{Matthew D.\} and Anokhin, \{Andrey P.\} and Bagot, \{Kara S.\} and Banich, \{Marie T.\} and Barch, \{Deanna M.\} and Arielle Baskin-Sommers and Breslin, \{Florence J.\} and Casey, \{B. J.\} and Bader Chaarani and Linda Chang and Clark, \{Duncan B.\} and Cloak, \{Christine C.\} and Constable, \{R. Todd\} and Cottler, \{Linda B.\} and Dagher, \{Rada K.\} and Mirella Dapretto and Dick, \{Anthony S.\} and Nico Dosenbach and Dowling, \{Gayathri J.\} and Dumas, \{Julie A.\} and Sarah Edwards and Thomas Ernst and Fair, \{Damien A.\} and Feldstein-Ewing, \{Sarah W.\} and Freedman, \{Edward G.\} and Fuemmeler, \{Bernard F.\} and Hugh Garavan and Gee, \{Dylan G.\} and Giedd, \{Jay N.\} and Glaser, \{Paul E.A.\} and Aimee Goldstone and Gray, \{Kevin M.\} and Hawes, \{Samuel W.\} and Heath, \{Andrew C.\} and Heitzeg, \{Mary M.\} and Hewitt, \{John K.\} and Heyser, \{Charles J.\} and Hoffman, \{Elizabeth A.\} and Huber, \{Rebekah S.\} and Huestis, \{Marilyn A.\} and Hyde, \{Luke W.\} and Infante, \{M. Alejandra\} and Ivanova, \{Masha Y.\} and Joanna Jacobus and Jernigan, \{Terry L.\} and Karcher, \{Nicole R.\} and Laird, \{Angela R.\} and LeBlanc, \{Kimberly H.\} and Krista Lisdahl and Monica Luciana and Beatriz Luna and Maes, \{Hermine H.\} and Marshall, \{Andrew T.\} and Mason, \{Michael J.\} and McGlade, \{Erin C.\} and Morris, \{Amanda S.\} and Nagel, \{Bonnie J.\} and Neigh, \{Gretchen N.\} and Palmer, \{Clare E.\} and Paulus, \{Martin P.\} and Potter, \{Alexandra S.\} and Puttler, \{Leon I.\} and Nishadi Rajapakse and Kristina Rapuano and Gloria Reeves and Renshaw, \{Perry F.\} and Claudiu Schirda and Sher, \{Kenneth J.\} and Chandni Sheth and Shilling, \{Paul D.\} and Squeglia, \{Lindsay M.\} and Sutherland, \{Matthew T.\} and Tapert, \{Susan F.\} and Tomko, \{Rachel L.\} and Deborah Yurgelun-Todd and Wade, \{Natasha E.\} and Weiss, \{Susan R.B.\} and Zucker, \{Robert A.\} and Sowell, \{Elizabeth R.\}",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Herting, Uban, Gonzalez, Baker, Kan, Thompson, Granger, Albaugh, Anokhin, Bagot, Banich, Barch, Baskin-Sommers, Breslin, Casey, Chaarani, Chang, Clark, Cloak, Constable, Cottler, Dagher, Dapretto, Dick, Dosenbach, Dowling, Dumas, Edwards, Ernst, Fair, Feldstein-Ewing, Freedman, Fuemmeler, Garavan, Gee, Giedd, Glaser, Goldstone, Gray, Hawes, Heath, Heitzeg, Hewitt, Heyser, Hoffman, Huber, Huestis, Hyde, Infante, Ivanova, Jacobus, Jernigan, Karcher, Laird, LeBlanc, Lisdahl, Luciana, Luna, Maes, Marshall, Mason, McGlade, Morris, Nagel, Neigh, Palmer, Paulus, Potter, Puttler, Rajapakse, Rapuano, Reeves, Renshaw, Schirda, Sher, Sheth, Shilling, Squeglia, Sutherland, Tapert, Tomko, Yurgelun-Todd, Wade, Weiss, Zucker and Sowell.",

year = "2021",

month = feb,

day = "18",

doi = "10.3389/fendo.2020.549928",

language = "English",

volume = "11",

journal = "Frontiers in Endocrinology",

issn = "1664-2392",

publisher = "Frontiers Media SA",

}

Herting, MM, Uban, KA, Gonzalez, MR, Baker, FC, Kan, EC, Thompson, WK, Granger, DA, Albaugh, MD, Anokhin, AP, Bagot, KS, Banich, MT, Barch, DM, Baskin-Sommers, A, Breslin, FJ, Casey, BJ, Chaarani, B, Chang, L, Clark, DB, Cloak, CC, Constable, RT, Cottler, LB, Dagher, RK, Dapretto, M, Dick, AS, Dosenbach, N, Dowling, GJ, Dumas, JA, Edwards, S, Ernst, T, Fair, DA, Feldstein-Ewing, SW, Freedman, EG, Fuemmeler, BF, Garavan, H, Gee, DG, Giedd, JN, Glaser, PEA, Goldstone, A, Gray, KM, Hawes, SW, Heath, AC, Heitzeg, MM, Hewitt, JK, Heyser, CJ, Hoffman, EA, Huber, RS, Huestis, MA, Hyde, LW, Infante, MA, Ivanova, MY, Jacobus, J, Jernigan, TL, Karcher, NR, Laird, AR, LeBlanc, KH, Lisdahl, K, Luciana, M, Luna, B, Maes, HH, Marshall, AT, Mason, MJ, McGlade, EC, Morris, AS, Nagel, BJ, Neigh, GN, Palmer, CE, Paulus, MP, Potter, AS, Puttler, LI, Rajapakse, N, Rapuano, K, Reeves, G, Renshaw, PF, Schirda, C, Sher, KJ, Sheth, C, Shilling, PD, Squeglia, LM, Sutherland, MT, Tapert, SF, Tomko, RL, Yurgelun-Todd, D, Wade, NE, Weiss, SRB, Zucker, RA & Sowell, ER 2021, 'Correspondence Between Perceived Pubertal Development and Hormone Levels in 9-10 Year-Olds From the Adolescent Brain Cognitive Development Study', Frontiers in Endocrinology, vol. 11, 549928. https://doi.org/10.3389/fendo.2020.549928

TY - JOUR

T1 - Correspondence Between Perceived Pubertal Development and Hormone Levels in 9-10 Year-Olds From the Adolescent Brain Cognitive Development Study

AU - Herting, Megan M.

AU - Uban, Kristina A.

AU - Gonzalez, Marybel Robledo

AU - Baker, Fiona C.

AU - Kan, Eric C.

AU - Thompson, Wesley K.

AU - Granger, Douglas A.

AU - Albaugh, Matthew D.

AU - Anokhin, Andrey P.

AU - Bagot, Kara S.

AU - Banich, Marie T.

AU - Barch, Deanna M.

AU - Baskin-Sommers, Arielle

AU - Breslin, Florence J.

AU - Casey, B. J.

AU - Chaarani, Bader

AU - Chang, Linda

AU - Clark, Duncan B.

AU - Cloak, Christine C.

AU - Constable, R. Todd

AU - Cottler, Linda B.

AU - Dagher, Rada K.

AU - Dapretto, Mirella

AU - Dick, Anthony S.

AU - Dosenbach, Nico

AU - Dowling, Gayathri J.

AU - Dumas, Julie A.

AU - Edwards, Sarah

AU - Ernst, Thomas

AU - Fair, Damien A.

AU - Feldstein-Ewing, Sarah W.

AU - Freedman, Edward G.

AU - Fuemmeler, Bernard F.

AU - Garavan, Hugh

AU - Gee, Dylan G.

AU - Giedd, Jay N.

AU - Glaser, Paul E.A.

AU - Goldstone, Aimee

AU - Gray, Kevin M.

AU - Hawes, Samuel W.

AU - Heath, Andrew C.

AU - Heitzeg, Mary M.

AU - Hewitt, John K.

AU - Heyser, Charles J.

AU - Hoffman, Elizabeth A.

AU - Huber, Rebekah S.

AU - Huestis, Marilyn A.

AU - Hyde, Luke W.

AU - Infante, M. Alejandra

AU - Ivanova, Masha Y.

AU - Jacobus, Joanna

AU - Jernigan, Terry L.

AU - Karcher, Nicole R.

AU - Laird, Angela R.

AU - LeBlanc, Kimberly H.

AU - Lisdahl, Krista

AU - Luciana, Monica

AU - Luna, Beatriz

AU - Maes, Hermine H.

AU - Marshall, Andrew T.

AU - Mason, Michael J.

AU - McGlade, Erin C.

AU - Morris, Amanda S.

AU - Nagel, Bonnie J.

AU - Neigh, Gretchen N.

AU - Palmer, Clare E.

AU - Paulus, Martin P.

AU - Potter, Alexandra S.

AU - Puttler, Leon I.

AU - Rajapakse, Nishadi

AU - Rapuano, Kristina

AU - Reeves, Gloria

AU - Renshaw, Perry F.

AU - Schirda, Claudiu

AU - Sher, Kenneth J.

AU - Sheth, Chandni

AU - Shilling, Paul D.

AU - Squeglia, Lindsay M.

AU - Sutherland, Matthew T.

AU - Tapert, Susan F.

AU - Tomko, Rachel L.

AU - Yurgelun-Todd, Deborah

AU - Wade, Natasha E.

AU - Weiss, Susan R.B.

AU - Zucker, Robert A.

AU - Sowell, Elizabeth R.

N1 - Publisher Copyright: © Copyright © 2021 Herting, Uban, Gonzalez, Baker, Kan, Thompson, Granger, Albaugh, Anokhin, Bagot, Banich, Barch, Baskin-Sommers, Breslin, Casey, Chaarani, Chang, Clark, Cloak, Constable, Cottler, Dagher, Dapretto, Dick, Dosenbach, Dowling, Dumas, Edwards, Ernst, Fair, Feldstein-Ewing, Freedman, Fuemmeler, Garavan, Gee, Giedd, Glaser, Goldstone, Gray, Hawes, Heath, Heitzeg, Hewitt, Heyser, Hoffman, Huber, Huestis, Hyde, Infante, Ivanova, Jacobus, Jernigan, Karcher, Laird, LeBlanc, Lisdahl, Luciana, Luna, Maes, Marshall, Mason, McGlade, Morris, Nagel, Neigh, Palmer, Paulus, Potter, Puttler, Rajapakse, Rapuano, Reeves, Renshaw, Schirda, Sher, Sheth, Shilling, Squeglia, Sutherland, Tapert, Tomko, Yurgelun-Todd, Wade, Weiss, Zucker and Sowell.

PY - 2021/2/18

Y1 - 2021/2/18

N2 - Aim: To examine individual variability between perceived physical features and hormones of pubertal maturation in 9–10-year-old children as a function of sociodemographic characteristics. Methods: Cross-sectional metrics of puberty were utilized from the baseline assessment of the Adolescent Brain Cognitive Development (ABCD) Study—a multi-site sample of 9–10 year-olds (n = 11,875)—and included perceived physical features via the pubertal development scale (PDS) and child salivary hormone levels (dehydroepiandrosterone and testosterone in all, and estradiol in females). Multi-level models examined the relationships among sociodemographic measures, physical features, and hormone levels. A group factor analysis (GFA) was implemented to extract latent variables of pubertal maturation that integrated both measures of perceived physical features and hormone levels. Results: PDS summary scores indicated more males (70%) than females (31%) were prepubertal. Perceived physical features and hormone levels were significantly associated with child’s weight status and income, such that more mature scores were observed among children that were overweight/obese or from households with low-income. Results from the GFA identified two latent factors that described individual differences in pubertal maturation among both females and males, with factor 1 driven by higher hormone levels, and factor 2 driven by perceived physical maturation. The correspondence between latent factor 1 scores (hormones) and latent factor 2 scores (perceived physical maturation) revealed synchronous and asynchronous relationships between hormones and concomitant physical features in this large young adolescent sample. Conclusions: Sociodemographic measures were associated with both objective hormone and self-report physical measures of pubertal maturation in a large, diverse sample of 9–10 year-olds. The latent variables of pubertal maturation described a complex interplay between perceived physical changes and hormone levels that hallmark sexual maturation, which future studies can examine in relation to trajectories of brain maturation, risk/resilience to substance use, and other mental health outcomes.

AB - Aim: To examine individual variability between perceived physical features and hormones of pubertal maturation in 9–10-year-old children as a function of sociodemographic characteristics. Methods: Cross-sectional metrics of puberty were utilized from the baseline assessment of the Adolescent Brain Cognitive Development (ABCD) Study—a multi-site sample of 9–10 year-olds (n = 11,875)—and included perceived physical features via the pubertal development scale (PDS) and child salivary hormone levels (dehydroepiandrosterone and testosterone in all, and estradiol in females). Multi-level models examined the relationships among sociodemographic measures, physical features, and hormone levels. A group factor analysis (GFA) was implemented to extract latent variables of pubertal maturation that integrated both measures of perceived physical features and hormone levels. Results: PDS summary scores indicated more males (70%) than females (31%) were prepubertal. Perceived physical features and hormone levels were significantly associated with child’s weight status and income, such that more mature scores were observed among children that were overweight/obese or from households with low-income. Results from the GFA identified two latent factors that described individual differences in pubertal maturation among both females and males, with factor 1 driven by higher hormone levels, and factor 2 driven by perceived physical maturation. The correspondence between latent factor 1 scores (hormones) and latent factor 2 scores (perceived physical maturation) revealed synchronous and asynchronous relationships between hormones and concomitant physical features in this large young adolescent sample. Conclusions: Sociodemographic measures were associated with both objective hormone and self-report physical measures of pubertal maturation in a large, diverse sample of 9–10 year-olds. The latent variables of pubertal maturation described a complex interplay between perceived physical changes and hormone levels that hallmark sexual maturation, which future studies can examine in relation to trajectories of brain maturation, risk/resilience to substance use, and other mental health outcomes.

KW - adolescent brain cognitive development

KW - dehydroepiandrosterone

KW - estradiol

KW - pubertal development scale

KW - puberty

KW - salivary hormones

KW - testosterone

UR - http://www.scopus.com/inward/record.url?scp=85102119371&partnerID=8YFLogxK

U2 - 10.3389/fendo.2020.549928

DO - 10.3389/fendo.2020.549928

M3 - Article

AN - SCOPUS:85102119371

SN - 1664-2392

VL - 11

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

M1 - 549928

ER -

Correspondence Between Perceived Pubertal Development and Hormone Levels in 9-10 Year-Olds From the Adolescent Brain Cognitive Development Study

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