Computer-aided diagnosis of Parkinson's disease using complex-valued neural networks and mRMR feature selection algorithm

Musa Peker, Baha Şen, Dursun Delen

Research output: Contribution to journalArticle

33 Scopus citations


Parkinson's disease (PD) is a neurological disorder which has a significant social and economic impact. PD is diagnosed by clinical observation and evaluations, coupled with a PD rating scale. However, these methods may be insufficient, especially in the initial phase of the disease. The processes are tedious and time-consuming, and hence systems that can automatically offer a diagnosis are needed. In this study, a novel method for the diagnosis of PD is proposed. Biomedical sound measurements obtained from continuous phonation samples were used as attributes. First, a minimum redundancy maximum relevance (mRMR) attribute selection algorithm was applied for the identification of the effective attributes. After conversion to a complex number, the resulting attributes are presented as input data to the complex-valued artificial neural network (CVANN). The proposed novel system might be a powerful tool for effective diagnosis of PD.

Original languageEnglish
Pages (from-to)281-302
Number of pages22
JournalJournal of Healthcare Engineering
Issue number3
Publication statusPublished - 1 Aug 2015
Externally publishedYes



  • Classification
  • Complex-valued neural network
  • Computer aided diagnosis
  • Mrmr feature selection method
  • Parkinson's disease

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