Abstract
Purpose: Alcohol Use Disorder disproportionately affects racial and ethnic groups due to limited healthcare access and socioeconomic factors. Addressing these disparities is crucial for tailoring clinical trials to meet diverse populations' needs to ensure better care and support. This study aimed to highlight gaps in diverse population representation in United States clinical trials on Alcohol Use Disorder.
Design methods: Systematic reviews were conducted in May 2024 using the medical literature databases, MEDLINE and Embase. Eligible studies were conducted in the United States, published or available between January 1, 2018 to December 31, 2023, and employed an intervention for people with Alcohol Use Disorder.
Publications were excluded if they were secondary database analyses, interim analyses, erratum, corrigendum, trials with international sites, trial updates, and studies combining Alcohol Use Disorder with comorbidities. A meta-analysis was conducted adhering strictly to The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data screening and extraction were performed by two authors independently. Comprehensive data extraction focused on predefined study characteristics and demographics.
Results/expected results: Statistical analyses included Participation-to-Disease Representation Ratios (PDRR) and representation ratings, which could be visualized by forest plots. Among 247 records analyzed, 26 met inclusion criteria and were further analyzed for diversity statistics like age, sex, and race/ethnicity Regarding the diversity ratings: None of the studies in our sample reported older adults and therefore received all poor ratings; Sex received only two "poor" ratings; and significantly, Race/Ethnicity received zero "Good" ratings.
Discussion/conclusion: These results express an important diversity gap for Alcohol Use Disorder clinical trials in the United States. The absence of adequate representation among Black, Asian, and Hispanic populations suggests a critical need for improved research methodologies and policies. Enhancing inclusivity in clinical trials is essential for developing Alcohol Use Disorder interventions that are tailored to diverse populations.
Design methods: Systematic reviews were conducted in May 2024 using the medical literature databases, MEDLINE and Embase. Eligible studies were conducted in the United States, published or available between January 1, 2018 to December 31, 2023, and employed an intervention for people with Alcohol Use Disorder.
Publications were excluded if they were secondary database analyses, interim analyses, erratum, corrigendum, trials with international sites, trial updates, and studies combining Alcohol Use Disorder with comorbidities. A meta-analysis was conducted adhering strictly to The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data screening and extraction were performed by two authors independently. Comprehensive data extraction focused on predefined study characteristics and demographics.
Results/expected results: Statistical analyses included Participation-to-Disease Representation Ratios (PDRR) and representation ratings, which could be visualized by forest plots. Among 247 records analyzed, 26 met inclusion criteria and were further analyzed for diversity statistics like age, sex, and race/ethnicity Regarding the diversity ratings: None of the studies in our sample reported older adults and therefore received all poor ratings; Sex received only two "poor" ratings; and significantly, Race/Ethnicity received zero "Good" ratings.
Discussion/conclusion: These results express an important diversity gap for Alcohol Use Disorder clinical trials in the United States. The absence of adequate representation among Black, Asian, and Hispanic populations suggests a critical need for improved research methodologies and policies. Enhancing inclusivity in clinical trials is essential for developing Alcohol Use Disorder interventions that are tailored to diverse populations.
| Original language | American English |
|---|---|
| Pages | 27 |
| State | Published - 13 Sep 2024 |
| Event | Symposium on Tribal and Rural Innovation in Disparities and Equity for Health - Tahlequah, United States Duration: 13 Sep 2024 → 13 Sep 2024 |
Conference
| Conference | Symposium on Tribal and Rural Innovation in Disparities and Equity for Health |
|---|---|
| Country/Territory | United States |
| City | Tahlequah |
| Period | 13/09/24 → 13/09/24 |