Complex interaction of dietary fat and Alaskan bog blueberry supplementation influences manganese mediated neurotoxicity and behavioral impairments

Malabika Maulik, Swarup Mitra, McKenzie Sweeney, Brianna Lu, Barbara E. Taylor, Abel Bult-Ito

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Dietary fat modulates neuronal health and contributes to age-related nervous system disorders. However, the complex interaction between dietary fat and supplementation and its consequences on neurotoxic pathophysiology has been sparsely explored. The indigenous Alaskan bog blueberry (BB), Vaccinum uliginosum, is known to have anti-inflammatory properties, mostly attributed to its rich polyphenolic content. Here, we evaluate the interplay between dietary fat and BB supplementation on sub-chronic manganese (Mn) exposure that inflicts neurotoxicity and behavioral impairments. In both low-fat and normal-fat diets, BB supplementation attenuated the behavioral and the molecular hallmarks of Mn-induced neurotoxicity. On the contrary, a high-fat diet was found to exacerbate these Mn-induced pathological features. Furthermore, BB supplementation failed to recover the behavioral deficits in mice subjected to a high fat diet in Mn-treated mice. Overall, our results demonstrate the importance of including a dietary regimen comprised of polyphenolic rich supplements with low-fat content in combating age-related neurodegenerative disorders.

Original languageEnglish
Pages (from-to)306-317
Number of pages12
JournalJournal of Functional Foods
Volume53
DOIs
StatePublished - Feb 2019

Keywords

  • Blueberry
  • High-fat diet
  • Low-fat diet
  • Manganese
  • Neurotoxicity

Fingerprint

Dive into the research topics of 'Complex interaction of dietary fat and Alaskan bog blueberry supplementation influences manganese mediated neurotoxicity and behavioral impairments'. Together they form a unique fingerprint.

Cite this