Complement Regulatory Proteins and Their Role in HCV-Related Pathogenesis

Batuel Okda, Anna Platt, Magdalene Quintero, Sarah Groover, Anil Kaul, Rashmi Kaul

Research output: Contribution to conferencePosterpeer-review

Abstract

Hepatitis C virus (HCV) liver infection will result in chronic inflammation of the liver in 80% of untreated cases. About 20% of the individuals with chronic inflammation develop the scarring of the liver called cirrhosis and about 5% of the individuals with cirrhosis will develop hepatocellular carcinoma (HCC). The complement system, a crucial component of the innate immune system serves as an important antimicrobial defense. HCV proteins inhibit the complement component thus inhibiting the cytolytic action resulting in increased viral persistence. Additionally, the viral proteins have been shown to modulate the expression of complement regulatory proteins’ (CRPs) CD55 and CD59 on hepatocytes. However, the role of CRPs in the development of HCV cirrhosis and the transition to HCC is poorly understood. In the current study, mRNA expression of CRPs CD46, CD55, and CD59 was analyzed in normal liver tissues and liver tissues of subjects with HCV-mediated cirrhosis and HCC. mRNA expression analysis of CRPs was conducted by qRT-PCR. The results indicated a differential mRNA expression of CRPs among the two diseased groups when compared to normal. There was an increasing trend in CD55 and CD59 mRNA expression in HCV cirrhosis and HCC liver tissues compared to normal, however these differences did not reach significance. No differences were detected in CD46 mRNA expression among the groups. Further studies with increased sample size will be useful to confirm these observations and involvement if any of CRPs in the process of HCV viral protein- mediated pathogenesis.

Cancer Sucks, Inc. (Bixby, OK) funded this study.
Original languageAmerican English
Pages69
StatePublished - 22 Feb 2021
EventOklahoma State University Center for Health Sciences Research Days 2021: Poster presentation - Oklahoma State University Center for Health Sciences Campus, Tulsa, United States
Duration: 22 Feb 202126 Feb 2021

Conference

ConferenceOklahoma State University Center for Health Sciences Research Days 2021
Country/TerritoryUnited States
CityTulsa
Period22/02/2126/02/21

Keywords

  • Hepatitis C Virus
  • Liver Cirrhosis
  • Hepatocellular Carcinoma (HCC)
  • Complement Regulatory Proteins

Fingerprint

Dive into the research topics of 'Complement Regulatory Proteins and Their Role in HCV-Related Pathogenesis'. Together they form a unique fingerprint.

Cite this