Comparison of the photothermal effects of 808 nm gold nanorod and indocyanine green solutions using an 805 nm diode laser

Aamr M. Hasanjee, Feifan Zhou, Connor West, Kegan Silk, Austin Doughty, Cody F. Bahavar, Wei R. Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Non-invasive laser immunotherapy (NLIT) is a treatment method for metastatic cancer which combines noninvasive laser irradiation with immunologically modified nanostructures to ablate a primary tumor and induce a systemic anti-tumor response. To further expand the development of NLIT, two different photosensitizing agents were compared: gold nanorods (GNR) with an optical absorption peak of 808 nm and indocyanine green (ICG) with an optical absorption peak of ∼800 nm. Various concentrations of GNR and ICG solutions were irradiated at different power densities using an 805 nm diode laser, and the temperature of the solutions was monitored during irradiation using a thermal camera. For comparison, dye balls made up of a 1:1 volume ratio of gel solution to GNR or ICG solution were placed in phantom gels and were then irradiated using the 805 nm diode laser to imitate the effect of laser irradiation on in vivo tumors. Non-invasive laser irradiation of GNR solution for 2 minutes resulted in a maximum increase in temperature by 31.8 °C. Additionally, similar irradiation of GNR solution dye ball within phantom gel for 10 minutes resulted in a maximum temperature increase of 8.2 °C. Comparatively, non-invasive laser irradiation of ICG solution for 2 minutes resulted in a maximum increase in temperature by 28.0 °C. Similar irradiation of ICG solution dye ball within phantom gel for 10 minutes yielded a maximum temperature increase of only 3.4 °C. Qualitatively, these studies showed that GNR solutions are more effective photosensitizing agents than ICG solution.

Original languageEnglish
Title of host publicationBiophotonics and Immune Responses XI
EditorsWei R. Chen
PublisherSPIE
ISBN (Electronic)9781628419436
DOIs
StatePublished - 1 Jan 2016
EventBiophotonics and Immune Responses XI - San Francisco, United States
Duration: 15 Feb 2016 → …

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9709
ISSN (Print)1605-7422

Conference

ConferenceBiophotonics and Immune Responses XI
CountryUnited States
CitySan Francisco
Period15/02/16 → …

Keywords

  • glycated chitosan
  • gold nanorods
  • indocyanine green
  • laser immunotherapy
  • single-walled carbon nanotubes

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    Hasanjee, A. M., Zhou, F., West, C., Silk, K., Doughty, A., Bahavar, C. F., & Chen, W. R. (2016). Comparison of the photothermal effects of 808 nm gold nanorod and indocyanine green solutions using an 805 nm diode laser. In W. R. Chen (Ed.), Biophotonics and Immune Responses XI (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9709). SPIE. https://doi.org/10.1117/12.2214631