Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia

Wenmei Shi, Hong Sheng Wang, Zongming Pan, Randy S. Wymore, Ira S. Cohen, David McKinnon, Jane E. Dixon

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

1. Three new members of the EAG potassium channel gene family were identified in rat and the complete coding sequence of one of these genes (elk1) was determined by cDNA cloning. 2. The elk1 gene, when expressed in Xenopus oocytes, encodes a slowly activating and slowly deactivating potassium channel. 3. The elk1 gene is expressed in sympathetic ganglia and is also expressed in sciatic nerve. 4. Six of the seven known EAG genes were found to be expressed in rat sympathetic ganglia, suggesting an important functional role for these channels in the sympathetic nervous system.

Original languageEnglish
Pages (from-to)675-682
Number of pages8
JournalJournal of Physiology
Volume511
Issue number3
DOIs
StatePublished - 15 Sep 1998

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