Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia

Wenmei Shi; Hong Sheng Wang; Zongming Pan; Randy S. Wymore; Ira S. Cohen; David McKinnon; Jane E. Dixon

doi:10.1111/j.1469-7793.1998.675bg.x

Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia

Wenmei Shi, Hong Sheng Wang, Zongming Pan, Randy S. Wymore, Ira S. Cohen, David McKinnon, Jane E. Dixon

Pharmacology and Physiology

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

1. Three new members of the EAG potassium channel gene family were identified in rat and the complete coding sequence of one of these genes (elk1) was determined by cDNA cloning. 2. The elk1 gene, when expressed in Xenopus oocytes, encodes a slowly activating and slowly deactivating potassium channel. 3. The elk1 gene is expressed in sympathetic ganglia and is also expressed in sciatic nerve. 4. Six of the seven known EAG genes were found to be expressed in rat sympathetic ganglia, suggesting an important functional role for these channels in the sympathetic nervous system.

Original language	English
Pages (from-to)	675-682
Number of pages	8
Journal	Journal of Physiology
Volume	511
Issue number	3
DOIs	https://doi.org/10.1111/j.1469-7793.1998.675bg.x
State	Published - 15 Sep 1998

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10.1111/j.1469-7793.1998.675bg.x

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title = "Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia",

abstract = "1. Three new members of the EAG potassium channel gene family were identified in rat and the complete coding sequence of one of these genes (elk1) was determined by cDNA cloning. 2. The elk1 gene, when expressed in Xenopus oocytes, encodes a slowly activating and slowly deactivating potassium channel. 3. The elk1 gene is expressed in sympathetic ganglia and is also expressed in sciatic nerve. 4. Six of the seven known EAG genes were found to be expressed in rat sympathetic ganglia, suggesting an important functional role for these channels in the sympathetic nervous system.",

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AU - Shi, Wenmei

AU - Wang, Hong Sheng

AU - Pan, Zongming

AU - Wymore, Randy S.

AU - Cohen, Ira S.

AU - McKinnon, David

AU - Dixon, Jane E.

PY - 1998/9/15

Y1 - 1998/9/15

N2 - 1. Three new members of the EAG potassium channel gene family were identified in rat and the complete coding sequence of one of these genes (elk1) was determined by cDNA cloning. 2. The elk1 gene, when expressed in Xenopus oocytes, encodes a slowly activating and slowly deactivating potassium channel. 3. The elk1 gene is expressed in sympathetic ganglia and is also expressed in sciatic nerve. 4. Six of the seven known EAG genes were found to be expressed in rat sympathetic ganglia, suggesting an important functional role for these channels in the sympathetic nervous system.

AB - 1. Three new members of the EAG potassium channel gene family were identified in rat and the complete coding sequence of one of these genes (elk1) was determined by cDNA cloning. 2. The elk1 gene, when expressed in Xenopus oocytes, encodes a slowly activating and slowly deactivating potassium channel. 3. The elk1 gene is expressed in sympathetic ganglia and is also expressed in sciatic nerve. 4. Six of the seven known EAG genes were found to be expressed in rat sympathetic ganglia, suggesting an important functional role for these channels in the sympathetic nervous system.

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JO - Journal of Physiology

JF - Journal of Physiology

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ER -

Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia

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