Clinical effects of laser immunotherapy on metastatic cancer patients

Mark F. Naylor, Anh K. Lam, Cody F. Bahavar, Robert E. Nordquist, Wei R. Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Clinical trials of late-stage breast cancer patients and late-stage melanoma patients treated by laser immunotherapy (LIT) have shown promising results. In a 2010 study of Li et al, eleven late-stage melanoma patients received LIT in one or multiple 6-week treatment cycles applied to a 200-cm2 treatment site, which usually contained multiple cutaneous metastases. Long-term, positive response was observed in six patients. All lesions in the treatment area of the patients responded to LIT, eight of which achieved complete local response (CLR). CLR was observed in the non-treatment site (regional) lesions in four patients. Five patients were still alive at the time of last follow-up. The probability of 12-month overall survival was 70%.2 In 2011, Li et al, treated ten late stage breast cancer patients with LIT.1 In 8 patients available for evaluation, the objective response rate was 62.5% and the clinical beneficial response rate was 75%.1 This review demonstrates that LIT is safe and well tolerated, so it can be easily applied on an outpatient basis and can be combined with other pharmaceutical modalities to improve the therapeutic response of metastatic cancers.

Original languageEnglish
Title of host publicationBiophotonics and Immune Responses XI
EditorsWei R. Chen
PublisherSPIE
ISBN (Electronic)9781628419436
DOIs
StatePublished - 1 Jan 2016
Externally publishedYes
EventBiophotonics and Immune Responses XI - San Francisco, United States
Duration: 15 Feb 2016 → …

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9709
ISSN (Print)1605-7422

Conference

ConferenceBiophotonics and Immune Responses XI
CountryUnited States
CitySan Francisco
Period15/02/16 → …

Keywords

  • breast cancer
  • clinical studies
  • Laser immunotherapy
  • melanoma
  • metastatic cancers
  • novel cancer therapy
  • systemic immune responses

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  • Cite this

    Naylor, M. F., Lam, A. K., Bahavar, C. F., Nordquist, R. E., & Chen, W. R. (2016). Clinical effects of laser immunotherapy on metastatic cancer patients. In W. R. Chen (Ed.), Biophotonics and Immune Responses XI (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9709). SPIE. https://doi.org/10.1117/12.2213891