Chronic antagonist infusion does not increase morphine antinociception in rat spinal cord

Craig W. Stevens; Tony L. Yaksh

doi:10.1016/0006-8993(87)90527-0

Chronic antagonist infusion does not increase morphine antinociception in rat spinal cord

Craig W. Stevens, Tony L. Yaksh

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Chronic spinal infusion of the opiate antagonist naloxone or naltrexone fail to influence the antinociceptive effect of subsequent intrathecal morphine on the hot plate test in rats compared to saline-infused controls. These results contrast the functional supersensitivity to morphine seen after long-term systemic opiate antagonist administration and support the hypothesis that dopaminergic interactions, lacking in the spinal cord, are necessary for antagonist-induced opioid receptor upregulation.

Original language	English
Pages (from-to)	388-390
Number of pages	3
Journal	Brain Research
Volume	425
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(87)90527-0
State	Published - 10 Nov 1987

Keywords

Antinociception
Morphine
Naloxone
Naltrexone
Opioid receptor
Upregulation

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10.1016/0006-8993(87)90527-0

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title = "Chronic antagonist infusion does not increase morphine antinociception in rat spinal cord",

abstract = "Chronic spinal infusion of the opiate antagonist naloxone or naltrexone fail to influence the antinociceptive effect of subsequent intrathecal morphine on the hot plate test in rats compared to saline-infused controls. These results contrast the functional supersensitivity to morphine seen after long-term systemic opiate antagonist administration and support the hypothesis that dopaminergic interactions, lacking in the spinal cord, are necessary for antagonist-induced opioid receptor upregulation.",

keywords = "Antinociception, Morphine, Naloxone, Naltrexone, Opioid receptor, Upregulation",

author = "Stevens, {Craig W.} and Yaksh, {Tony L.}",

note = "Funding Information: The authors thank Ms. Ann Johnson for expert manuscrippt reparationa,n d V. Mancini Stevensfo r carefulp roofreadingS.u pportedb y the Mayo Foun-dationa ndNIH Grant DA-02110.",

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T1 - Chronic antagonist infusion does not increase morphine antinociception in rat spinal cord

AU - Stevens, Craig W.

AU - Yaksh, Tony L.

N1 - Funding Information: The authors thank Ms. Ann Johnson for expert manuscrippt reparationa,n d V. Mancini Stevensfo r carefulp roofreadingS.u pportedb y the Mayo Foun-dationa ndNIH Grant DA-02110.

PY - 1987/11/10

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N2 - Chronic spinal infusion of the opiate antagonist naloxone or naltrexone fail to influence the antinociceptive effect of subsequent intrathecal morphine on the hot plate test in rats compared to saline-infused controls. These results contrast the functional supersensitivity to morphine seen after long-term systemic opiate antagonist administration and support the hypothesis that dopaminergic interactions, lacking in the spinal cord, are necessary for antagonist-induced opioid receptor upregulation.

AB - Chronic spinal infusion of the opiate antagonist naloxone or naltrexone fail to influence the antinociceptive effect of subsequent intrathecal morphine on the hot plate test in rats compared to saline-infused controls. These results contrast the functional supersensitivity to morphine seen after long-term systemic opiate antagonist administration and support the hypothesis that dopaminergic interactions, lacking in the spinal cord, are necessary for antagonist-induced opioid receptor upregulation.

KW - Antinociception

KW - Morphine

KW - Naloxone

KW - Naltrexone

KW - Opioid receptor

KW - Upregulation

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DO - 10.1016/0006-8993(87)90527-0

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AN - SCOPUS:0023574316

SN - 0006-8993

VL - 425

SP - 388

EP - 390

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Chronic antagonist infusion does not increase morphine antinociception in rat spinal cord

Abstract

Keywords

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