Characterization of a recombinant bacteriocin with potent activities against Clostridioides difficile

I-Hsiu Huang, Hsiang-Ning Chang, Yu-Jen Jiang, Yuan-Pin Hung, Jenn-Wei Chen, Joseph McCreary

Research output: Contribution to conferencePosterpeer-review

Abstract

George (I-Hsiu) Huang, PhD; Faculty; george.huang@okstate.edu Hsiang-Ning Chang, MS, Yu-Jen Jiang, MS, Yuan-Pin Hung, MD, PhD, Jenn-Wei Chen, PhD, Joseph McCreary, BS



Clostridioides difficile is a spore-forming gram-positive bacteria and is the leading cause of antibiotic-associated dirrhea in hospitals worldwide. Immunocompromised conditions and disruptions of gut microbiota are risk factors for C. difficile infections (CDI). Currently no vaccines are available for the prevention of CDI and there are concerns for development of additional antibiotic resistance. In this study, we identified and characterized a bacteriocin from the probiotic Clostridium butyricum Miyari. Recombinant bacteriocin displayed a narrow spectrum of activity against only genus Clostridium and Clostridioides . Importantly, the recombinant bacteriocin displayed potent activity against C. difficile both in vitro and ex vivo. This study demonstrate the potential of developing alternative treatment strategies against CDI.
Original languageAmerican English
Pages52
StatePublished - 22 Feb 2021
EventOklahoma State University Center for Health Sciences Research Days 2021: Poster presentation - Oklahoma State University Center for Health Sciences Campus, Tulsa, United States
Duration: 22 Feb 202126 Feb 2021

Conference

ConferenceOklahoma State University Center for Health Sciences Research Days 2021
Country/TerritoryUnited States
CityTulsa
Period22/02/2126/02/21

Keywords

  • C. Difficile
  • Bacteriocin
  • Probiotic

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