Cerebrolysin Alleviating Effect on Glutamate-Mediated Neuroinflammation Via Glutamate Transporters and Oxidative Stress

Seydanur Avci, Sukran Gunaydin, Neziha Senem Ari, Emine Karaca Sulukoglu, Ozlem Erol Polat, Ibrahim Gecili, Yesim Yeni, Aysegul Yilmaz, Sidika Genc, Ahmet Hacimuftuoglu, Serkan Yildirim, Muhammed Yasser Mokresh, Damla Gul Findik, Aristidis Tsatsakis, Denisa Margina, Konstantinos Tsarouhas, David R. Wallace, Ali Taghizadehghalehjoughi

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Glutamate, one of the most important excitatory neurotransmitters, acts as a signal transducer in peripheral tissues and endocrine cells. Excessive glutamate secretion has been shown to cause excitotoxicity and neurodegenerative disease. Cerebrolysin is a mixture of enzymatically treated peptides derived from pig brain including neurotrophic factors, like brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and ciliary neurotrophic factor (CNTF). The present study investigated the protective effects of cerebrolysin on glutamate transporters (EAAT 1, EAAT 2) and cytokines (IL-1β and IL-10) activity in glutamate-mediated neurotoxicity. Primary cortex neuron culture was exposed to glutamate and successively treated with various cerebrolysin concentrations for 24 and 48 h. Our data showed that cerebrolysin primarily protects neurons by decreasing glutamate concentration in the synaptic cleft. In addition, Cerebrolysin can decrease oxidative stress and neuron cell damage by increasing antioxidant activity and decreasing inflammation cytokine levels.

Original languageEnglish
Pages (from-to)2292-2302
Number of pages11
JournalJournal of Molecular Neuroscience
Volume72
Issue number11
DOIs
StatePublished - Nov 2022

Keywords

  • EAAT 1
  • EAAT 2
  • Glutamate
  • IL-10
  • IL-1β
  • LDH

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