Central and peripheral actions of alpha2-adrenergic agonists on renal function in Long-Evans and Brattleboro rats

R. Dawson, D. R. Wallace

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The effects of 3 α2-adrenergic receptor agonists on renal function in vasopressin (AVP)-deficient Brattleboro (DI) rats were evaluated. The aim of this study was to determine the relative contribution of central versus peripheral α2-adrenoceptors in mediating diuresis and natriuresis, as well as the role of α2-adrenoceptors in antagonizing the actions of AVP. In addition to the studies of renal function, the effects of AVP deficiency on renal α2-adrenoceptor affinity and number was evaluated along with determination of peripheral catecholamine stores. The centrally acting α2-adrenergic agonists guanabenz and guanfacine significantly increased urine output and sodium excretion in Long-Evans (LE) rats. Guanabenz and guanfacine increased urine output in DI rats but failed to increase sodium excretion. The polar α2-adrenergic agonist, ST-91, increased sodium excretion in both LE and DI rats, however, at a dose of 1.0 mg/kg urine output was significantly decreased in DI rats. The 3 α2-adrenergic agonists increased potassium excretion in LE rats, but at the 1.0-mg/kg dose of guanabenz and ST-91, potassium excretion was significantly inhibited in DI rats. Renal α2-adrenergic receptors and norepinephrine stores were not altered in DI rats. Adrenal NE stores were significantly elevated in DI rats relative to LE rats. The results of this study suggest that in the absence of AVP, centrally acting α2-adrenergic agonists have limited natriuretic action, although peripheral activation of α2-adrenoceptors is sufficient to elicit natriuresis irrespective of the presence of AVP. The chronic deficiency of AVP does not alter renal α2-adrenergic receptor number, but the natriuretic and kaliuretic actions of α2-adrenergic agonists are altered in DI rats.

Original languageEnglish
Pages (from-to)240-252
Number of pages13
JournalPharmacology
Volume39
Issue number4
DOIs
StatePublished - 1989

Keywords

  • Brattleboro rats
  • Guanabenz
  • Norepinephrine
  • α-Adrenoceptors

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