Category-specific integration of homeostatic signals in caudal but not rostral human insula

W. Kyle Simmons, Kristina M. Rapuano, Seth J. Kallman, John E. Ingeholm, Bernard Miller, Stephen J. Gotts, Jason A. Avery, Kevin D. Hall, Alex Martin

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Abstract

Prevailing theories hold that the insula is functionally organized along its caudal-to-rostral axis, with posterior regions coding lower-level sensory information and anterior regions coding higher-level stimulus significance relative to the body's homeostatic needs. Contrary to predictions of this model, the response of the taste-sensitive region of the caudal, but not rostral, insula to food images was directly related to the body's homeostatic state as indexed by levels of peripheral glucose.

Original languageEnglish
Pages (from-to)1551-1552
Number of pages2
JournalNature Neuroscience
Volume16
Issue number11
DOIs
StatePublished - 1 Nov 2013
Externally publishedYes

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Simmons, W. K., Rapuano, K. M., Kallman, S. J., Ingeholm, J. E., Miller, B., Gotts, S. J., Avery, J. A., Hall, K. D., & Martin, A. (2013). Category-specific integration of homeostatic signals in caudal but not rostral human insula. Nature Neuroscience, 16(11), 1551-1552. https://doi.org/10.1038/nn.3535