Cardiovascular function and circadian patterns in rats after area postrema lesions or prolonged food restriction

Kathleen S. Curtis, Eric G. Krause, Robert J. Contreras

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The role of the area postrema (AP) in baseline cardiovascular function was evaluated by radio telemetry in rats with lesions of AP (APX), along with the effect of APX on circadian patterns of cardiovascular function and ingestive behavior. Despite lesion-induced hypophagia and body weight loss, APX did not affect circadian patterns of mean arterial pressure (MAP), heart rate (HR), or ingestion but did cause a substantial decrease (-60 bpm) in resting HR. The bradycardia was not attributable to weight loss, as resting HR in weight-matched controls, though decreased from baseline, was significantly greater than that in rats with APX. In weight-matched controls, HR increased slightly when weight returned to baseline; however, the bradycardia persisted in rats with APX. These results suggest that AP contributes to resting HR, independent of weight loss or changes in circadian patterns of HR or MAP.

Original languageEnglish
Pages (from-to)46-50
Number of pages5
JournalNeuroscience Letters
Volume350
Issue number1
DOIs
StatePublished - 16 Oct 2003

Keywords

  • Blood pressure
  • Circumventricular organ
  • Feeding
  • Heart rate
  • Water intake

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