Cardiopulmonary sympathetic afferent input does not require dorsal column pathways to excite C1-C3 spinal cells in rats

Jianhua Zhang, Margaret J. Chandler, Kenneth Miller, Robert D. Foreman

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Effects of electrically stimulating the left stellate ganglion to activate cardiopulmonary sympathetic afferent (CPSA) fibers were determined on C1-C3 dorsal horn neurons in anaesthetized rats. Fifty-two of 53 dorsal horn neurons affected by CPSA stimulation were excited and one neuron was inhibited. In 6 experiments, dorsal columns and ventrolateral funiculi were sequentially lesioned to determine neuronal pathways involved in CPSA activation of C1-C3 neurons. In 6 additional experiments, spinal transection at rostral C1 was used to determine the contribution of supraspinal relays. We concluded that CPSA input to C1-C3 segments travelled bilaterally in ventrolateral pathways, and that supraspinal relays were not required for CPSA excitation of C1-C3 neurons. These results suggest that neurons in C1-C3 segments might play an important role in processing visceral spinal afferent information.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalBrain Research
Volume771
Issue number1
DOIs
StatePublished - 10 Oct 1997

Fingerprint

Posterior Horn Cells
Neurons
Visceral Afferents
Stellate Ganglion
Adrenergic Fibers

Keywords

  • Referred pain
  • Spinal cord lesions
  • Ventrolateral funiculus
  • Visceral nociception
  • Viscerosomatic convergence

Cite this

Zhang, Jianhua ; Chandler, Margaret J. ; Miller, Kenneth ; Foreman, Robert D. / Cardiopulmonary sympathetic afferent input does not require dorsal column pathways to excite C1-C3 spinal cells in rats. In: Brain Research. 1997 ; Vol. 771, No. 1. pp. 25-30.
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Cardiopulmonary sympathetic afferent input does not require dorsal column pathways to excite C1-C3 spinal cells in rats. / Zhang, Jianhua; Chandler, Margaret J.; Miller, Kenneth; Foreman, Robert D.

In: Brain Research, Vol. 771, No. 1, 10.10.1997, p. 25-30.

Research output: Contribution to journalArticle

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