Breast cancer survivors' health-related quality of life: Racial differences and comparisons with noncancer controls

Electra D. Paskett, Catherine M. Alfano, Mario A. Davidson, Barbara L. Andersen, Michelle J. Naughton, Aurora Sherman, Paige Green McDonald, Jennifer Hays

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

BACKGROUND. Small samples with few minority women and/or the absence of comparisons to peers without cancer histories have limited previous research suggesting racial differences in breast cancer survivors' health-related quality of life (HRQoL). This study not only compared HRQoL of African American and white breast cancer survivors, but also compared the HRQoL of these women to that of same-race women with no cancer history. METHODS. Data from the Women's Health Initiative-Observational Study were used, including 5021 cancer survivors and 88,532 women without a history of cancer. Multivariate regression analyses estimated differences in breast cancersurvivors' baseline HRQoL (RAND36), depressive symptoms (CES-D short-form), and sleep quality (WHIIRS). RESULTS. African American breast cancer survivors reported worse physical functioning and general health compared with white survivors. Among African Americans, survivors reported worse role limitations due to physical health, pain, general health, and vitality than women without a history of cancer. This was most evident in those with more recent diagnoses. Most significant differences between groups were small in magnitude (Cohen d = .21-.36). CONCLUSIONS. These results add to the increasing knowledge of cancer disparities by showing that African American women have small, but clinically meaningful, decrements in physical HRQoL compared with white survivors and with African American women without cancer. Because African American women also face diagnosis with higher grade tumors and higher breast cancer mortality, more research is needed to examine the physical and psychosocial experiences of African American breast cancer survivors to elucidate the mechanisms leading to poorer outcomes.

Original languageEnglish
Pages (from-to)3222-3230
Number of pages9
JournalCancer
Volume113
Issue number11
DOIs
StatePublished - 1 Dec 2008

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Survivors
African Americans
Quality of Life
Breast Neoplasms
Neoplasms
Women's Health
Health
Research
Observational Studies
Sleep
Breast
Multivariate Analysis
Regression Analysis
Depression
Pain
Mortality

Keywords

  • Breast cancer
  • Health status
  • Quality of life
  • Race

Cite this

Paskett, E. D., Alfano, C. M., Davidson, M. A., Andersen, B. L., Naughton, M. J., Sherman, A., ... Hays, J. (2008). Breast cancer survivors' health-related quality of life: Racial differences and comparisons with noncancer controls. Cancer, 113(11), 3222-3230. https://doi.org/10.1002/cncr.23891
Paskett, Electra D. ; Alfano, Catherine M. ; Davidson, Mario A. ; Andersen, Barbara L. ; Naughton, Michelle J. ; Sherman, Aurora ; McDonald, Paige Green ; Hays, Jennifer. / Breast cancer survivors' health-related quality of life : Racial differences and comparisons with noncancer controls. In: Cancer. 2008 ; Vol. 113, No. 11. pp. 3222-3230.
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abstract = "BACKGROUND. Small samples with few minority women and/or the absence of comparisons to peers without cancer histories have limited previous research suggesting racial differences in breast cancer survivors' health-related quality of life (HRQoL). This study not only compared HRQoL of African American and white breast cancer survivors, but also compared the HRQoL of these women to that of same-race women with no cancer history. METHODS. Data from the Women's Health Initiative-Observational Study were used, including 5021 cancer survivors and 88,532 women without a history of cancer. Multivariate regression analyses estimated differences in breast cancersurvivors' baseline HRQoL (RAND36), depressive symptoms (CES-D short-form), and sleep quality (WHIIRS). RESULTS. African American breast cancer survivors reported worse physical functioning and general health compared with white survivors. Among African Americans, survivors reported worse role limitations due to physical health, pain, general health, and vitality than women without a history of cancer. This was most evident in those with more recent diagnoses. Most significant differences between groups were small in magnitude (Cohen d = .21-.36). CONCLUSIONS. These results add to the increasing knowledge of cancer disparities by showing that African American women have small, but clinically meaningful, decrements in physical HRQoL compared with white survivors and with African American women without cancer. Because African American women also face diagnosis with higher grade tumors and higher breast cancer mortality, more research is needed to examine the physical and psychosocial experiences of African American breast cancer survivors to elucidate the mechanisms leading to poorer outcomes.",
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Paskett, ED, Alfano, CM, Davidson, MA, Andersen, BL, Naughton, MJ, Sherman, A, McDonald, PG & Hays, J 2008, 'Breast cancer survivors' health-related quality of life: Racial differences and comparisons with noncancer controls', Cancer, vol. 113, no. 11, pp. 3222-3230. https://doi.org/10.1002/cncr.23891

Breast cancer survivors' health-related quality of life : Racial differences and comparisons with noncancer controls. / Paskett, Electra D.; Alfano, Catherine M.; Davidson, Mario A.; Andersen, Barbara L.; Naughton, Michelle J.; Sherman, Aurora; McDonald, Paige Green; Hays, Jennifer.

In: Cancer, Vol. 113, No. 11, 01.12.2008, p. 3222-3230.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Breast cancer survivors' health-related quality of life

T2 - Racial differences and comparisons with noncancer controls

AU - Paskett, Electra D.

AU - Alfano, Catherine M.

AU - Davidson, Mario A.

AU - Andersen, Barbara L.

AU - Naughton, Michelle J.

AU - Sherman, Aurora

AU - McDonald, Paige Green

AU - Hays, Jennifer

PY - 2008/12/1

Y1 - 2008/12/1

N2 - BACKGROUND. Small samples with few minority women and/or the absence of comparisons to peers without cancer histories have limited previous research suggesting racial differences in breast cancer survivors' health-related quality of life (HRQoL). This study not only compared HRQoL of African American and white breast cancer survivors, but also compared the HRQoL of these women to that of same-race women with no cancer history. METHODS. Data from the Women's Health Initiative-Observational Study were used, including 5021 cancer survivors and 88,532 women without a history of cancer. Multivariate regression analyses estimated differences in breast cancersurvivors' baseline HRQoL (RAND36), depressive symptoms (CES-D short-form), and sleep quality (WHIIRS). RESULTS. African American breast cancer survivors reported worse physical functioning and general health compared with white survivors. Among African Americans, survivors reported worse role limitations due to physical health, pain, general health, and vitality than women without a history of cancer. This was most evident in those with more recent diagnoses. Most significant differences between groups were small in magnitude (Cohen d = .21-.36). CONCLUSIONS. These results add to the increasing knowledge of cancer disparities by showing that African American women have small, but clinically meaningful, decrements in physical HRQoL compared with white survivors and with African American women without cancer. Because African American women also face diagnosis with higher grade tumors and higher breast cancer mortality, more research is needed to examine the physical and psychosocial experiences of African American breast cancer survivors to elucidate the mechanisms leading to poorer outcomes.

AB - BACKGROUND. Small samples with few minority women and/or the absence of comparisons to peers without cancer histories have limited previous research suggesting racial differences in breast cancer survivors' health-related quality of life (HRQoL). This study not only compared HRQoL of African American and white breast cancer survivors, but also compared the HRQoL of these women to that of same-race women with no cancer history. METHODS. Data from the Women's Health Initiative-Observational Study were used, including 5021 cancer survivors and 88,532 women without a history of cancer. Multivariate regression analyses estimated differences in breast cancersurvivors' baseline HRQoL (RAND36), depressive symptoms (CES-D short-form), and sleep quality (WHIIRS). RESULTS. African American breast cancer survivors reported worse physical functioning and general health compared with white survivors. Among African Americans, survivors reported worse role limitations due to physical health, pain, general health, and vitality than women without a history of cancer. This was most evident in those with more recent diagnoses. Most significant differences between groups were small in magnitude (Cohen d = .21-.36). CONCLUSIONS. These results add to the increasing knowledge of cancer disparities by showing that African American women have small, but clinically meaningful, decrements in physical HRQoL compared with white survivors and with African American women without cancer. Because African American women also face diagnosis with higher grade tumors and higher breast cancer mortality, more research is needed to examine the physical and psychosocial experiences of African American breast cancer survivors to elucidate the mechanisms leading to poorer outcomes.

KW - Breast cancer

KW - Health status

KW - Quality of life

KW - Race

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Paskett ED, Alfano CM, Davidson MA, Andersen BL, Naughton MJ, Sherman A et al. Breast cancer survivors' health-related quality of life: Racial differences and comparisons with noncancer controls. Cancer. 2008 Dec 1;113(11):3222-3230. https://doi.org/10.1002/cncr.23891