Trillions of bacteria, archaea, fungi, and viruses comprise the human microbiome and virome. The composition and diversity of these complex communities have a profound impact on the health of their human or animal host. Embedded in these communities might be groupings such as individual bacterial species/strains or consortia that have key roles and could serve as biomarkers for host health and disease. We are collecting microbiota and microbiome profiles from humans and animals to identify such specific markers for dietary intake, inflammation, infection, and other health or disease related outcomes. Next-generation sequencing systems are used for 16S ribosomal RNA analyses and whole-genome shotgun metagenomics to determine taxonomic profiles and predict functional profiles of the microbial communities. Correlation of these profiles with host metadata will aid in the identification of potential biomarkers of health and disease. Examples of workflows and bioinformatic approaches will be presented that illustrate how biomarkers discovery could lead to novel diagnostic targets and preventative or therapeutic interventions.
|Original language||American English|
|State||Published - 4 Nov 2022|
|Event||111th Annual Technical Meeting, Oklahoma Academy of Science - Oklahoma State University Center for Health Sciences, Tulsa, United States|
Duration: 4 Nov 2022 → 4 Nov 2022
|Conference||111th Annual Technical Meeting, Oklahoma Academy of Science|
|Abbreviated title||OAS Meeting 2022|
|Period||4/11/22 → 4/11/22|