Bilateral large mature teratomas in a 45-year-old nulligravida woman with a family history of ovarian cancer

Ovarian teratomas are germ cell tumors that can be benign (mature) or malignant (immature). Individuals usually present with lower abdominal pain. Teratomas can have sizes of over 30 cm and contain tissues derived from endoderm, mesoderm, and ectoderm. Here, we describe a 45-year-old nulligravida female with bilateral mature ovarian teratomas, the larger of which exceeded 11 cm. The patient’s enlarged, fibroid-filled uterus and ovaries were carefully extracted in the operating room and examined. Fragmentation of each teratoma yielded copious amounts of hair, teeth, and sebaceous material. Neither histology nor tumor markers indicated malignancy. It is unknown whether the patient’s experience of substance use contributed to her condition or increased her risk for future malignant transformation.