@article{e6b9677063d64e609be52dcc606a527b,
title = "Behavioral phenotyping and pathological indicators of Parkinson's disease in C. elegans models",
abstract = "Parkinson's disease (PD) is a neurodegenerative disorder with symptoms that progressively worsen with age. Pathologically, PD is characterized by the aggregation of a-synuclein in cells of the substantia nigra in the brain and loss of dopaminergic neurons. This pathology is associated with impaired movement and reduced cognitive function. The etiology of PD can be attributed to a combination of environmental and genetic factors. A popular animal model, the nematode roundworm Caenorhabditis elegans, has been frequently used to study the role of genetic and environmental factors in the molecular pathology and behavioral phenotypes associated with PD. The current review summarizes cellular markers and behavioral phenotypes in transgenic and toxin-induced PD models of C. elegans.",
keywords = "Behavioral phenotyping, Caenorhabditis elegans (C. elegans), Dopamine, Parkinson's disease (PD), Pathological markers",
author = "Malabika Maulik and Swarup Mitra and Abel Bult-Ito and Taylor, {Barbara E.} and Vayndorf, {Elena M.}",
note = "Funding Information: The authors thank Mitchell Reed for his help with confocal microscopy. This research was funded by grants from the National Institute of General Medical Sciences of the National Institutes of Health (1) under an Institutional Development Award (IDeA; grant number P20GM103395) and (2) under a Building Infrastructure Leading to Diversity Award (BUILD; three linked grants numbered RL5GM118990, TL4 GM118992, and 1UL1GM118991). The work is solely the responsibility of the authors and does not necessarily represent the official view of the National Institutes of Health. We thank the office of the Vice Chancellor of Research, Dr. Larry Hinzman, for funding associated with the publication costs of this article. Publisher Copyright: {\textcopyright} 2017 Maulik, Mitra, Bult-Ito, Taylor and Vayndorf.",
year = "2017",
doi = "10.3389/fgene.2017.00077",
language = "English",
volume = "8",
journal = "Frontiers in Genetics",
issn = "1664-8021",
publisher = "Frontiers Media S.A.",
number = "JUN",
}