Behavioral effects of morphine, levorphanol, dextrorphan and naloxone in the frog Rana pipiens

Paul D. Pezalla, Craig Stevens

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Systemic morphine induces explosive motor behavior and generalized muscular rigidity in frogs. Naloxone does not reverse either of these effects of morphine but at high doses causes muscular flaccidity and unresponsiveness to stimulation. Intraspinal morphine induces rigidity, but not explosive motor behavior, and this action is blocked by naloxone. Behavioral effects are seen rarely after intraspinal levorphanol (rigidity) and never after intraspinal dextrorphan or naloxone. In contrast to systemic morphine and naloxone, systemic levorphanol and dextrorphan are lethal to frogs at high doses.

Original languageEnglish
Pages (from-to)213-217
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume21
Issue number2
DOIs
StatePublished - 1 Jan 1984

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Levorphanol
Dextrorphan
Rana pipiens
Naloxone
Anura
Morphine
Rigidity
Muscle Rigidity
Muscle Hypotonia

Keywords

  • Amphibians
  • Dextrorphan
  • Levorphanol
  • Morphine
  • Naloxone
  • Opiates
  • Rana pipiens

Cite this

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abstract = "Systemic morphine induces explosive motor behavior and generalized muscular rigidity in frogs. Naloxone does not reverse either of these effects of morphine but at high doses causes muscular flaccidity and unresponsiveness to stimulation. Intraspinal morphine induces rigidity, but not explosive motor behavior, and this action is blocked by naloxone. Behavioral effects are seen rarely after intraspinal levorphanol (rigidity) and never after intraspinal dextrorphan or naloxone. In contrast to systemic morphine and naloxone, systemic levorphanol and dextrorphan are lethal to frogs at high doses.",
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Behavioral effects of morphine, levorphanol, dextrorphan and naloxone in the frog Rana pipiens. / Pezalla, Paul D.; Stevens, Craig.

In: Pharmacology, Biochemistry and Behavior, Vol. 21, No. 2, 01.01.1984, p. 213-217.

Research output: Contribution to journalArticle

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