Abstract
A new molecular rearrangement, the aza-Quasi-Favorskii rearrangement, has been developed for the construction of highly substituted aziridines. Electron-deficient O-sulfonyl oximes react readily with α,α-disubstituted acetophenone-derived enolates to furnish highly substituted aziridines via this unprecedented domino process. In-depth computational studies reveal an asynchronous yet concerted nitrenoid-type rearrangement pathway.
Original language | English |
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Pages (from-to) | 10943-10949 |
Number of pages | 7 |
Journal | Journal of the American Chemical Society |
Volume | 144 |
Issue number | 24 |
DOIs | |
State | Published - 22 Jun 2022 |
Externally published | Yes |