Atropine-induced cutaneous vasodilation decreases esophageal temperature during exercise

M. A. Kolka, L. A. Stephenson, A. E. Allan, P. B. Rock

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Four healthy adult males volunteered for this study, which followed informed-consent procedures administered by our local Human Use Committee. Esophageal (T(es)) and mean skin (T(sk), eight site) temperatures, forearm sweating rate (ṁ(s)), metabolism (M), heart rate (HR), and forearm blood flow (FBF) were measured at rest and during exercise [55% oxygen consumption (V̇O2) peak] during control experiments and after 2 mg im atropine (ATR). Experiments were randomized and separated by at least 72 h. ATR increased heart rate at rest by 15 beats/min and during exercise by 24 beats/min. ATR decreased whole body sweating by 57%. All eight local skin temperatures were higher in ATR than in control. T(sk) was 32.6°C in ATR and 31.0°C in control (P < 0.01). During exercise, ATR increased vasodilation of the forearm compared with control. The slope of FBF to T(es) increased over 300% in ATR experiments compared with control (P < 0.05). The higher sensible heat flux from this vasodilation decreased T(es) during exercise, which further decreased sweating. Skin blood flow remained elevated as T(es) ed, suggesting that local vasodilatory factors promoted atropine-induced cutaneous vasodilation.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume257
Issue number5
StatePublished - 1 Jan 1989

Fingerprint

Atropine
Vasodilation
Exercise
Skin
Temperature
Forearm
Sweating
Heart Rate
Skin Temperature
Informed Consent
Oxygen Consumption
Hot Temperature

Keywords

  • body temperature regulation
  • plethysmography
  • sweating

Cite this

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title = "Atropine-induced cutaneous vasodilation decreases esophageal temperature during exercise",
abstract = "Four healthy adult males volunteered for this study, which followed informed-consent procedures administered by our local Human Use Committee. Esophageal (T(es)) and mean skin (T(sk), eight site) temperatures, forearm sweating rate (ṁ(s)), metabolism (M), heart rate (HR), and forearm blood flow (FBF) were measured at rest and during exercise [55{\%} oxygen consumption (V̇O2) peak] during control experiments and after 2 mg im atropine (ATR). Experiments were randomized and separated by at least 72 h. ATR increased heart rate at rest by 15 beats/min and during exercise by 24 beats/min. ATR decreased whole body sweating by 57{\%}. All eight local skin temperatures were higher in ATR than in control. T(sk) was 32.6°C in ATR and 31.0°C in control (P < 0.01). During exercise, ATR increased vasodilation of the forearm compared with control. The slope of FBF to T(es) increased over 300{\%} in ATR experiments compared with control (P < 0.05). The higher sensible heat flux from this vasodilation decreased T(es) during exercise, which further decreased sweating. Skin blood flow remained elevated as T(es) ed, suggesting that local vasodilatory factors promoted atropine-induced cutaneous vasodilation.",
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Atropine-induced cutaneous vasodilation decreases esophageal temperature during exercise. / Kolka, M. A.; Stephenson, L. A.; Allan, A. E.; Rock, P. B.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 257, No. 5, 01.01.1989.

Research output: Contribution to journalArticle

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AU - Stephenson, L. A.

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