Associations between time spent sitting and cancer-related biomarkers in postmenopausal women: an exploration of effect modifiers

Raheem J. Paxton, Su Yon Jung, Mara Z. Vitolins, Jenifer Fenton, Electra Paskett, Michael Pollak, Jennifer Hays-Grudo, Stephen D. Hursting, Shine Chang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: Despite evidence that prolonged periods of sitting may influence biological mediators of cancer development, few studies have considered these relationships in a cancer-specific context.

Methods: This cross-sectional study included 755 postmenopausal women enrolled in an ancillary study of the Women’s Health Initiative. Plasma levels of Insulin-like growth factor-I (IGF-I), IGF-binding protein-3, leptin, insulin, C-peptide, C-reactive protein (CRP), and Interleukin (IL)-6 were measured. The time spent sitting per day was categorized as quartiles (Qs). The relationships between sedentary time and biomarkers were modified by race, physical activity, and exogenous estrogen use.

Results: IGF-I levels among African American (AA) women were higher than those of white women across the Qs of sedentary time. Likewise, IL-6 levels in AA women were higher than those in white women at Q3 and Q4 of sedentary time. IGFBP-3 levels were higher and insulin levels were lower across the Qs of sedentary time among women meeting guidelines for physical activity than women who were not. Additionally, CRP levels were higher among estrogen users than nonusers at Q1, Q2, and Q4 of sedentary time.

Conclusions: These results suggest that relationship between time spent sitting and cancer-related biomarkers may not be simply linear, but differ in the context of effect modifiers.

Original languageEnglish
Pages (from-to)1427-1437
Number of pages11
JournalCancer Causes and Control
Volume25
Issue number11
DOIs
StatePublished - 31 Oct 2014

Fingerprint

Tumor Biomarkers
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
African Americans
C-Reactive Protein
Interleukin-6
Estrogens
Exercise
Insulin
C-Peptide
Women's Health
Leptin
Neoplasms
Cross-Sectional Studies
Biomarkers
Guidelines

Keywords

  • Cancer-relevant biomarkers
  • Effect modifier
  • Postmenopausal women
  • Sedentary behavior

Cite this

Paxton, Raheem J. ; Jung, Su Yon ; Vitolins, Mara Z. ; Fenton, Jenifer ; Paskett, Electra ; Pollak, Michael ; Hays-Grudo, Jennifer ; Hursting, Stephen D. ; Chang, Shine. / Associations between time spent sitting and cancer-related biomarkers in postmenopausal women : an exploration of effect modifiers. In: Cancer Causes and Control. 2014 ; Vol. 25, No. 11. pp. 1427-1437.
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Associations between time spent sitting and cancer-related biomarkers in postmenopausal women : an exploration of effect modifiers. / Paxton, Raheem J.; Jung, Su Yon; Vitolins, Mara Z.; Fenton, Jenifer; Paskett, Electra; Pollak, Michael; Hays-Grudo, Jennifer; Hursting, Stephen D.; Chang, Shine.

In: Cancer Causes and Control, Vol. 25, No. 11, 31.10.2014, p. 1427-1437.

Research output: Contribution to journalArticle

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AU - Paxton, Raheem J.

AU - Jung, Su Yon

AU - Vitolins, Mara Z.

AU - Fenton, Jenifer

AU - Paskett, Electra

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AU - Hays-Grudo, Jennifer

AU - Hursting, Stephen D.

AU - Chang, Shine

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