Assessing the reporting of harms in systematic reviews focused on platelet-rich plasma therapy: a cross-sectional analysis

Shaelyn Ward; Kade Ezell; Audrey Wise; Morgan Garrett; Brayden Rucker; Drew Lestersmith; Mohammed Emam; Matt Vassar

doi:10.2217/rme-2023-0058

Assessing the reporting of harms in systematic reviews focused on platelet-rich plasma therapy: a cross-sectional analysis

Shaelyn Ward, Kade Ezell, Audrey Wise, Morgan Garrett, Brayden Rucker, Drew Lestersmith, Mohammed Emam, Matt Vassar

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: Our objectives are: to evaluate the completeness of harms reporting in systematic reviews (SRs) on platelet-rich plasma therapy; to assess the overall methodological quality of the SR using AMSTAR-2 tool; to assess harms reporting overlap in primary studies between SRs. Materials & methods: The authors searched five database systems for relevant literature on platelet rich plasma therapy. The authors screened and extracted in masked, duplicate fashion. Results: All SRs reported less than 50% completeness in harms reporting. The most frequently reported item was harms being stated in the abstract or title (26/103, 25.2%). AMSTAR-2 assessed 96 SRs as 'critically low', 6 SRs as 'low' and 1 'moderate'. Conclusion: Our study highlights that reporting of harms should become more standardized and transparent.

Original language	English
Pages (from-to)	531-542
Number of pages	12
Journal	Regenerative Medicine
Volume	18
Issue number	7
DOIs	https://doi.org/10.2217/rme-2023-0058
State	Published - 1 Jul 2023

Keywords

PRP
cell therapy
harms
plasma
platelet-rich plasma
regeneration
repair
therapy

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abstract = "Aim: Our objectives are: to evaluate the completeness of harms reporting in systematic reviews (SRs) on platelet-rich plasma therapy; to assess the overall methodological quality of the SR using AMSTAR-2 tool; to assess harms reporting overlap in primary studies between SRs. Materials & methods: The authors searched five database systems for relevant literature on platelet rich plasma therapy. The authors screened and extracted in masked, duplicate fashion. Results: All SRs reported less than 50% completeness in harms reporting. The most frequently reported item was harms being stated in the abstract or title (26/103, 25.2%). AMSTAR-2 assessed 96 SRs as 'critically low', 6 SRs as 'low' and 1 'moderate'. Conclusion: Our study highlights that reporting of harms should become more standardized and transparent.",

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AU - Wise, Audrey

AU - Garrett, Morgan

AU - Rucker, Brayden

AU - Lestersmith, Drew

AU - Emam, Mohammed

AU - Vassar, Matt

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Assessing the reporting of harms in systematic reviews focused on platelet-rich plasma therapy: a cross-sectional analysis

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Keywords

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