Area postrema lesions in rats appear to disrupt rapid feedback inhibition of fluid intake

Kathleen S. Curtis; Joseph G. Verbalis; Edward M. Stricker

doi:10.1016/0006-8993(96)00277-6

Area postrema lesions in rats appear to disrupt rapid feedback inhibition of fluid intake

Kathleen S. Curtis, Joseph G. Verbalis, Edward M. Stricker

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Abstract

Area postrema lesions (APX) were produced by vacuum aspiration in adult male rats. After systemic administration of hypertonic saline solutions, significantly more water was consumed by rats with APX than by intact control rats. Similarly enhanced water intake by rats with APX also was observed when marked hypovolemia was induced by s.c. administration of a hyperoncotic colloidal solution. In both conditions, the increased water intake occurred within the first 15 min of the drinking tests. Intakes of liquid diet or 10% sucrose solution after food deprivation by rats with APX also were considerably larger than those of control rats. These and other results suggest that rats with APX experience less inhibition of ingestion while drinking. Thus, the AP may be important for the detection of early, inhibitory signals generated by fluid ingestion, and after its ablation increased drinking may occur because the feedback inhibition provided by such signals is diminished.

Original language	English
Pages (from-to)	31-38
Number of pages	8
Journal	Brain Research
Volume	726
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(96)00277-6
State	Published - 8 Jul 1996

Keywords

Area postrema
Hypertonic NaCl solution
Hypovolemia
Sucrose
Thirst
Water intake

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10.1016/0006-8993(96)00277-6

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title = "Area postrema lesions in rats appear to disrupt rapid feedback inhibition of fluid intake",

abstract = "Area postrema lesions (APX) were produced by vacuum aspiration in adult male rats. After systemic administration of hypertonic saline solutions, significantly more water was consumed by rats with APX than by intact control rats. Similarly enhanced water intake by rats with APX also was observed when marked hypovolemia was induced by s.c. administration of a hyperoncotic colloidal solution. In both conditions, the increased water intake occurred within the first 15 min of the drinking tests. Intakes of liquid diet or 10% sucrose solution after food deprivation by rats with APX also were considerably larger than those of control rats. These and other results suggest that rats with APX experience less inhibition of ingestion while drinking. Thus, the AP may be important for the detection of early, inhibitory signals generated by fluid ingestion, and after its ablation increased drinking may occur because the feedback inhibition provided by such signals is diminished.",

keywords = "Area postrema, Hypertonic NaCl solution, Hypovolemia, Sucrose, Thirst, Water intake",

author = "Curtis, {Kathleen S.} and Verbalis, {Joseph G.} and Stricker, {Edward M.}",

note = "Funding Information: This research was supported in part by National Institute of Mental Health Research Grant MH-25140 (MERIT Award). Portions of this report were presented in preliminary form at the Society for Neuroscience meeting in Washington, DC, November 1993.",

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AU - Curtis, Kathleen S.

AU - Verbalis, Joseph G.

AU - Stricker, Edward M.

N1 - Funding Information: This research was supported in part by National Institute of Mental Health Research Grant MH-25140 (MERIT Award). Portions of this report were presented in preliminary form at the Society for Neuroscience meeting in Washington, DC, November 1993.

PY - 1996/7/8

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N2 - Area postrema lesions (APX) were produced by vacuum aspiration in adult male rats. After systemic administration of hypertonic saline solutions, significantly more water was consumed by rats with APX than by intact control rats. Similarly enhanced water intake by rats with APX also was observed when marked hypovolemia was induced by s.c. administration of a hyperoncotic colloidal solution. In both conditions, the increased water intake occurred within the first 15 min of the drinking tests. Intakes of liquid diet or 10% sucrose solution after food deprivation by rats with APX also were considerably larger than those of control rats. These and other results suggest that rats with APX experience less inhibition of ingestion while drinking. Thus, the AP may be important for the detection of early, inhibitory signals generated by fluid ingestion, and after its ablation increased drinking may occur because the feedback inhibition provided by such signals is diminished.

AB - Area postrema lesions (APX) were produced by vacuum aspiration in adult male rats. After systemic administration of hypertonic saline solutions, significantly more water was consumed by rats with APX than by intact control rats. Similarly enhanced water intake by rats with APX also was observed when marked hypovolemia was induced by s.c. administration of a hyperoncotic colloidal solution. In both conditions, the increased water intake occurred within the first 15 min of the drinking tests. Intakes of liquid diet or 10% sucrose solution after food deprivation by rats with APX also were considerably larger than those of control rats. These and other results suggest that rats with APX experience less inhibition of ingestion while drinking. Thus, the AP may be important for the detection of early, inhibitory signals generated by fluid ingestion, and after its ablation increased drinking may occur because the feedback inhibition provided by such signals is diminished.

KW - Area postrema

KW - Hypertonic NaCl solution

KW - Hypovolemia

KW - Sucrose

KW - Thirst

KW - Water intake

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AN - SCOPUS:0030575277

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SP - 31

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JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

Area postrema lesions in rats appear to disrupt rapid feedback inhibition of fluid intake

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Keywords

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