Aprotinin in the management of coagulopathy associated with amniotic fluid embolus

Jeffrey Stroup, G. Davin Haraway, J. Martin Beal

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Amniotic fluid embolus, also known as anaphylactoid syndrome of pregnancy, is a rare complication of pregnancy. When it occurs, the maternal mortality rate may be as high as 86%, and in survivors, the morbidity rate may be just as high. Hallmark clinical features include maternal cardiovascular collapse with cyanosis, cardiopulmonary arrest, hypotension, hemorrhage associated with disseminated intravascular coagulation, and fetal distress. Management centers on strategies to improve oxygenation, support circulation, and correct the coagulopathy We report the case of a patient who developed amniotic fluid embolus and was effectively managed with aprotinin to control the coagulopathy associated with this devastating complication of pregnancy.

Original languageEnglish
Pages (from-to)689-693
Number of pages5
JournalPharmacotherapy
Volume26
Issue number5 I
DOIs
StatePublished - 1 Jan 2006

Fingerprint

Aprotinin
Pregnancy Complications
Amniotic Fluid
Embolism
Fetal Distress
Cyanosis
Maternal Mortality
Disseminated Intravascular Coagulation
Heart Arrest
Hypotension
Survivors
Mothers
Hemorrhage
Morbidity
Pregnancy
Mortality

Keywords

  • Amniotic fluid embolus
  • Anaphylactoid syndrome of pregnancy
  • Aprotinin
  • Coagulopathy

Cite this

Stroup, Jeffrey ; Haraway, G. Davin ; Beal, J. Martin. / Aprotinin in the management of coagulopathy associated with amniotic fluid embolus. In: Pharmacotherapy. 2006 ; Vol. 26, No. 5 I. pp. 689-693.
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Aprotinin in the management of coagulopathy associated with amniotic fluid embolus. / Stroup, Jeffrey; Haraway, G. Davin; Beal, J. Martin.

In: Pharmacotherapy, Vol. 26, No. 5 I, 01.01.2006, p. 689-693.

Research output: Contribution to journalArticle

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