Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model

Joseph T. Acquaviva, Cody F. Bahavar, Feifan Zhou, Xiaosong Li, Eric W. Howard, Liz C. Bullen, Ricardo P. Silvy, Wei R. Chen

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The ideal treatment modality for metastatic cancer would be a local treatment that can destroy primary tumors while inducing an effective systemic anti-tumor response. To this end, we developed laser immunotherapy, combining photothermal laser application with an immunoadjuvant for the treatment of metastatic cancer. Additionally, to enhance the selective photothermal effect, we integrated light-absorbing nanomaterials into this innovative treatment. Specifically, we developed an immunologically modified carbon nanotube combining single-walled carbon nanotubes (SWNTs) with the immunoadjuvant glycated chitosan (GC). To determine the effectiveness of laser irradiation, a series of experiments were performed using two different irradiation durations - 5 and 10 min. Rats were inoculated with DMBA-4 cancer cells, a metastatic cancer cell line. The treatment group of rats receiving laser irradiation for 10 min had a 50% long-term survival rate without residual primary or metastatic tumors. The treatment group of rats receiving laser irradiation for 5 min had no long-term survivors; all rats died with multiple metastases at several distant sites. Therefore, Laser+SWNT-GC treatment with 10 min of laser irradiation proved to be effective at reducing tumor size and inducing long-term anti-tumor immunity.

Original languageEnglish
Article number1550036
JournalJournal of Innovative Optical Health Sciences
Volume8
Issue number4
DOIs
StatePublished - 25 Jul 2015
Externally publishedYes

Keywords

  • Anti-tumor immune response
  • glycated chitosan
  • laser immunotherapy
  • laser irradiation
  • single-walled carbon nanotubes

Fingerprint Dive into the research topics of 'Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model'. Together they form a unique fingerprint.

  • Cite this