Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model

Joseph T. Acquaviva, Aamr M. Hasanjee, Cody F. Bahavar, Feifan Zhou, Hong Liu, Eric W. Howard, Liz C. Bullen, Ricardo P. Silvy, Wei R. Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Laser immunotherapy (LIT) is being developed as a treatment modality for metastatic cancer which can destroy primary tumors and induce effective systemic anti-tumor responses by using a targeted treatment approach in conjunction with the use of a novel immunoadjuvant, glycated chitosan (GC). In this study, Non-invasive Laser Immunotherapy (NLIT) was used as the primary treatment mode. We incorporated single-walled carbon nanotubes (SWNTs) into the treatment regimen to boost the tumor-killing effect of LIT. SWNTs and GC were conjugated to create a completely novel, immunologically modified carbon nanotube (SWNT-GC). To determine the efficacy of different laser irradiation durations, 5 minutes or 10 minutes, a series of experiments were performed. Rats were inoculated with DMBA-4 cancer cells, a highly aggressive metastatic cancer cell line. Half of the treatment group of rats receiving laser irradiation for 10 minutes survived without primary or metastatic tumors. The treatment group of rats receiving laser irradiation for 5 minutes had no survivors. Thus, Laser+SWNT-GC treatment with 10 minutes of laser irradiation proved to be effective at reducing tumor size and inducing long-term anti-tumor immunity.

Original languageEnglish
Title of host publicationBiophotonics and Immune Responses X
EditorsWei R. Chen
PublisherSPIE
ISBN (Electronic)9781628414141
DOIs
StatePublished - 1 Jan 2015
Externally publishedYes
EventBiophotonics and Immune Responses X - San Francisco, United States
Duration: 9 Feb 201510 Feb 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9324
ISSN (Print)1605-7422

Conference

ConferenceBiophotonics and Immune Responses X
CountryUnited States
CitySan Francisco
Period9/02/1510/02/15

Keywords

  • Anti-tumor response
  • Glycated chitosan (GC)
  • Laser immunotherapy (LIT)
  • Single-walled carbon nanotubes (SWNTs)

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  • Cite this

    Acquaviva, J. T., Hasanjee, A. M., Bahavar, C. F., Zhou, F., Liu, H., Howard, E. W., Bullen, L. C., Silvy, R. P., & Chen, W. R. (2015). Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model. In W. R. Chen (Ed.), Biophotonics and Immune Responses X [932415-1] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9324). SPIE. https://doi.org/10.1117/12.2080890