Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model

Joseph T. Acquaviva; Aamr M. Hasanjee; Cody F. Bahavar; Feifan Zhou; Hong Liu; Eric W. Howard; Liz C. Bullen; Ricardo P. Silvy; Wei R. Chen

doi:10.1117/12.2080890

Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model

Joseph T. Acquaviva, Aamr M. Hasanjee, Cody F. Bahavar, Feifan Zhou, Hong Liu, Eric W. Howard, Liz C. Bullen, Ricardo P. Silvy, Wei R. Chen

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Laser immunotherapy (LIT) is being developed as a treatment modality for metastatic cancer which can destroy primary tumors and induce effective systemic anti-tumor responses by using a targeted treatment approach in conjunction with the use of a novel immunoadjuvant, glycated chitosan (GC). In this study, Non-invasive Laser Immunotherapy (NLIT) was used as the primary treatment mode. We incorporated single-walled carbon nanotubes (SWNTs) into the treatment regimen to boost the tumor-killing effect of LIT. SWNTs and GC were conjugated to create a completely novel, immunologically modified carbon nanotube (SWNT-GC). To determine the efficacy of different laser irradiation durations, 5 minutes or 10 minutes, a series of experiments were performed. Rats were inoculated with DMBA-4 cancer cells, a highly aggressive metastatic cancer cell line. Half of the treatment group of rats receiving laser irradiation for 10 minutes survived without primary or metastatic tumors. The treatment group of rats receiving laser irradiation for 5 minutes had no survivors. Thus, Laser+SWNT-GC treatment with 10 minutes of laser irradiation proved to be effective at reducing tumor size and inducing long-term anti-tumor immunity.

Original language	English
Title of host publication	Biophotonics and Immune Responses X
Editors	Wei R. Chen
Publisher	SPIE
ISBN (Electronic)	9781628414141
DOIs	https://doi.org/10.1117/12.2080890
State	Published - 1 Jan 2015
Externally published	Yes
Event	Biophotonics and Immune Responses X - San Francisco, United States Duration: 9 Feb 2015 → 10 Feb 2015

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	9324
ISSN (Print)	1605-7422

Conference

Conference	Biophotonics and Immune Responses X
Country/Territory	United States
City	San Francisco
Period	9/02/15 → 10/02/15

Keywords

Anti-tumor response
Glycated chitosan (GC)
Laser immunotherapy (LIT)
Single-walled carbon nanotubes (SWNTs)

Access to Document

10.1117/12.2080890

Cite this

Acquaviva, J. T., Hasanjee, A. M., Bahavar, C. F., Zhou, F., Liu, H., Howard, E. W., Bullen, L. C., Silvy, R. P., & Chen, W. R. (2015). Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model. In W. R. Chen (Ed.), Biophotonics and Immune Responses X Article 932415-1 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9324). SPIE. https://doi.org/10.1117/12.2080890

@inproceedings{46050b9045114973b00102cabd306d82,

title = "Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model",

abstract = "Laser immunotherapy (LIT) is being developed as a treatment modality for metastatic cancer which can destroy primary tumors and induce effective systemic anti-tumor responses by using a targeted treatment approach in conjunction with the use of a novel immunoadjuvant, glycated chitosan (GC). In this study, Non-invasive Laser Immunotherapy (NLIT) was used as the primary treatment mode. We incorporated single-walled carbon nanotubes (SWNTs) into the treatment regimen to boost the tumor-killing effect of LIT. SWNTs and GC were conjugated to create a completely novel, immunologically modified carbon nanotube (SWNT-GC). To determine the efficacy of different laser irradiation durations, 5 minutes or 10 minutes, a series of experiments were performed. Rats were inoculated with DMBA-4 cancer cells, a highly aggressive metastatic cancer cell line. Half of the treatment group of rats receiving laser irradiation for 10 minutes survived without primary or metastatic tumors. The treatment group of rats receiving laser irradiation for 5 minutes had no survivors. Thus, Laser+SWNT-GC treatment with 10 minutes of laser irradiation proved to be effective at reducing tumor size and inducing long-term anti-tumor immunity.",

keywords = "Anti-tumor response, Glycated chitosan (GC), Laser immunotherapy (LIT), Single-walled carbon nanotubes (SWNTs)",

author = "Acquaviva, {Joseph T.} and Hasanjee, {Aamr M.} and Bahavar, {Cody F.} and Feifan Zhou and Hong Liu and Howard, {Eric W.} and Bullen, {Liz C.} and Silvy, {Ricardo P.} and Chen, {Wei R.}",

note = "Publisher Copyright: {\textcopyright} 2015 SPIE.; Biophotonics and Immune Responses X ; Conference date: 09-02-2015 Through 10-02-2015",

year = "2015",

month = jan,

day = "1",

doi = "10.1117/12.2080890",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Chen, {Wei R.}",

booktitle = "Biophotonics and Immune Responses X",

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Acquaviva, JT, Hasanjee, AM, Bahavar, CF, Zhou, F, Liu, H, Howard, EW, Bullen, LC, Silvy, RP & Chen, WR 2015, Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model. in WR Chen (ed.), Biophotonics and Immune Responses X., 932415-1, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9324, SPIE, Biophotonics and Immune Responses X, San Francisco, United States, 9/02/15. https://doi.org/10.1117/12.2080890

Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model. / Acquaviva, Joseph T.; Hasanjee, Aamr M.; Bahavar, Cody F. et al.
Biophotonics and Immune Responses X. ed. / Wei R. Chen. SPIE, 2015. 932415-1 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9324).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model

AU - Acquaviva, Joseph T.

AU - Hasanjee, Aamr M.

AU - Bahavar, Cody F.

AU - Zhou, Feifan

AU - Liu, Hong

AU - Howard, Eric W.

AU - Bullen, Liz C.

AU - Silvy, Ricardo P.

AU - Chen, Wei R.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Laser immunotherapy (LIT) is being developed as a treatment modality for metastatic cancer which can destroy primary tumors and induce effective systemic anti-tumor responses by using a targeted treatment approach in conjunction with the use of a novel immunoadjuvant, glycated chitosan (GC). In this study, Non-invasive Laser Immunotherapy (NLIT) was used as the primary treatment mode. We incorporated single-walled carbon nanotubes (SWNTs) into the treatment regimen to boost the tumor-killing effect of LIT. SWNTs and GC were conjugated to create a completely novel, immunologically modified carbon nanotube (SWNT-GC). To determine the efficacy of different laser irradiation durations, 5 minutes or 10 minutes, a series of experiments were performed. Rats were inoculated with DMBA-4 cancer cells, a highly aggressive metastatic cancer cell line. Half of the treatment group of rats receiving laser irradiation for 10 minutes survived without primary or metastatic tumors. The treatment group of rats receiving laser irradiation for 5 minutes had no survivors. Thus, Laser+SWNT-GC treatment with 10 minutes of laser irradiation proved to be effective at reducing tumor size and inducing long-term anti-tumor immunity.

AB - Laser immunotherapy (LIT) is being developed as a treatment modality for metastatic cancer which can destroy primary tumors and induce effective systemic anti-tumor responses by using a targeted treatment approach in conjunction with the use of a novel immunoadjuvant, glycated chitosan (GC). In this study, Non-invasive Laser Immunotherapy (NLIT) was used as the primary treatment mode. We incorporated single-walled carbon nanotubes (SWNTs) into the treatment regimen to boost the tumor-killing effect of LIT. SWNTs and GC were conjugated to create a completely novel, immunologically modified carbon nanotube (SWNT-GC). To determine the efficacy of different laser irradiation durations, 5 minutes or 10 minutes, a series of experiments were performed. Rats were inoculated with DMBA-4 cancer cells, a highly aggressive metastatic cancer cell line. Half of the treatment group of rats receiving laser irradiation for 10 minutes survived without primary or metastatic tumors. The treatment group of rats receiving laser irradiation for 5 minutes had no survivors. Thus, Laser+SWNT-GC treatment with 10 minutes of laser irradiation proved to be effective at reducing tumor size and inducing long-term anti-tumor immunity.

KW - Anti-tumor response

KW - Glycated chitosan (GC)

KW - Laser immunotherapy (LIT)

KW - Single-walled carbon nanotubes (SWNTs)

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U2 - 10.1117/12.2080890

DO - 10.1117/12.2080890

M3 - Conference contribution

AN - SCOPUS:84928537006

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Biophotonics and Immune Responses X

A2 - Chen, Wei R.

PB - SPIE

T2 - Biophotonics and Immune Responses X

Y2 - 9 February 2015 through 10 February 2015

ER -

Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model

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Keywords

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