Objective: Clinical practice guidelines (CPGs) are essential to clinical decision-making as their recommendations are supported by published literature. Systematic reviews are considered the highest quality of evidence used to underpin these guidelines. However, research to support these recommendations may lack compliance to quality reporting among systematic reviews (SRs). Here, we aim to evaluate the quality of SRs underpinning CPG recommendations for the management of head and neck cancer (HNC).

Methods: Using PubMed, we searched for CPGs pertinent to the management of head and neck cancer published between January 2017 and May 2021. Relevant guidelines were analyzed for all SRs. Cited SRs in CPGswere evaluated using A Measurement Tool to Assess Systematic Reviews-2 (AMSTAR2) and PreferredReporting Items for Systematic Reviews and Meta-Analyses (PRISMA) instruments. Study characteristics were extracted in a masked triplicate fashion.

Results: A total of 16 CPGs and 142 unique SRs were included in our study. PRISMA completion ranged from 67.15%-87.65% across CPGs with a mean of 76.41% (SD=16.9). AMSTAR-2 completion ranged from 34.38%-84.38% across CPGs with a mean of 67.55% (SD=20.9) among all SRs. The lowest rated items included funding sources and publication bias. Higher score was achieved in SR done by Cochrane group and it was only 2.11% (3/142) of all SR’s quoted in CPG.

Conclusion: Adherence to AMSTAR-2 and PRISMA items exhibits a variation among SRs cited in CPGs for the management of HNC. Reporting funding sources, investigating publication bias, and implementing.
Original languageAmerican English
StatePublished - 18 Feb 2022
EventOklahoma State University Center for Health Sciences Research Week 2022 : Poster Presentation - Oklahoma State University Center for Health Sciences, Tulsa, United States
Duration: 14 Feb 202218 Feb 2022


ConferenceOklahoma State University Center for Health Sciences Research Week 2022
Country/TerritoryUnited States


  • Head and neck cancer
  • clinical practice guidelines
  • systematic reviews
  • AMSTAR-2
  • meta-analysis


Dive into the research topics of 'Analysis of Systematic Reviews in Clinical Practice Guidelines for Head and Neck Cancer'. Together they form a unique fingerprint.

Cite this