TY - JOUR
T1 - An optimized method for sample collection, extraction, and analysis of fentanyl and fentanyl analogs from a non-porous surface
AU - Ciesielski, Austin L.
AU - Wagner, Jarrad R.
AU - Alexander-Scott, Marissa
AU - Snawder, John
N1 - Funding Information:
Research supported by the U.S. Department of Justice , National Institute of Justice, United States through the Interagency Agreement “ Fentanyl and Fentalog Detection for Public Safety and Remediation ” ( DJO-NIJ-18-RO-0506 ), awarded to CDC-NIOSH, Cincinnati, OH.
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/6/1
Y1 - 2021/6/1
N2 - Illicit use of the potent opioid fentanyl and its analogs (fentanyls) are on the rise in the United States. As use increases, drug production tends to also increase, leading to more locations being contaminated with the potentially lethal substance. Because fentanyl-contaminated locations may present a risk to the general public, a method for sampling, identifying, and quantitating these fentanyls from surfaces is in need. This research developed and optimized a surface-wipe collection and extraction method for 17 fentanyls and 10 common fentanyl adulterants from a non-porous surface and quantitated the amount of each compound collected with liquid chromatography tandem mass spectrometry. The final, optimized surface-wipe method resulted in an average collection and extraction efficiency (±SD) of 62.0 (±14.0)%, with a range of 34.1 (±2.6) – 82.5 (±9.6)%. While legislation has yet to be implemented regarding remediation levels for fentanyl-contaminated locations, when such legislation is drafted, this method can be implemented to determine the safety of these locations prior to and after decontamination has occurred.
AB - Illicit use of the potent opioid fentanyl and its analogs (fentanyls) are on the rise in the United States. As use increases, drug production tends to also increase, leading to more locations being contaminated with the potentially lethal substance. Because fentanyl-contaminated locations may present a risk to the general public, a method for sampling, identifying, and quantitating these fentanyls from surfaces is in need. This research developed and optimized a surface-wipe collection and extraction method for 17 fentanyls and 10 common fentanyl adulterants from a non-porous surface and quantitated the amount of each compound collected with liquid chromatography tandem mass spectrometry. The final, optimized surface-wipe method resulted in an average collection and extraction efficiency (±SD) of 62.0 (±14.0)%, with a range of 34.1 (±2.6) – 82.5 (±9.6)%. While legislation has yet to be implemented regarding remediation levels for fentanyl-contaminated locations, when such legislation is drafted, this method can be implemented to determine the safety of these locations prior to and after decontamination has occurred.
KW - Fentanyl
KW - Fentanyl analog
KW - LC-MS/MS
KW - Surface wipes
KW - Swabbing
UR - http://www.scopus.com/inward/record.url?scp=85101414031&partnerID=8YFLogxK
U2 - 10.1016/j.talanta.2021.122210
DO - 10.1016/j.talanta.2021.122210
M3 - Article
C2 - 33773711
AN - SCOPUS:85101414031
SN - 0039-9140
VL - 228
JO - Talanta
JF - Talanta
M1 - 122210
ER -