Amphotericin B formulation confusion and mortality in an HIV-seropositive patient

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Abstract

Amphotericin B (AmB) is commonly used in patients with a human immunodeficiency virus (HIV)-positive diagnosis for the treatment of disseminated fungal infections such as Histoplasma spp. or Cryptococcus spp. Newer liposomal formulations of AmB have been introduced to the market to avoid the toxic effects of the traditional agent. With the introduction of these new agents, there is a risk of confusion between the agents in regards to dosing, which may lead to toxicity. We report the case of an HIV-seropositive patient who inadvertently received five times the dose of AmB deoxycholate for disseminated Histoplasma capsulatum and died.

Original languageEnglish
Pages (from-to)532-536
Number of pages5
JournalHospital Pharmacy
Volume42
Issue number6
DOIs
StatePublished - 1 Jan 2007

Fingerprint

Histoplasma
Amphotericin B
Viruses
HIV
Cryptococcus
Mortality
Mycoses
Poisons
Toxicity
Therapeutics
liposomal amphotericin B
deoxycholate drug combination amphotericin B

Keywords

  • Amphotericin B
  • HIV
  • Histoplasmosis
  • Liposomal

Cite this

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title = "Amphotericin B formulation confusion and mortality in an HIV-seropositive patient",
abstract = "Amphotericin B (AmB) is commonly used in patients with a human immunodeficiency virus (HIV)-positive diagnosis for the treatment of disseminated fungal infections such as Histoplasma spp. or Cryptococcus spp. Newer liposomal formulations of AmB have been introduced to the market to avoid the toxic effects of the traditional agent. With the introduction of these new agents, there is a risk of confusion between the agents in regards to dosing, which may lead to toxicity. We report the case of an HIV-seropositive patient who inadvertently received five times the dose of AmB deoxycholate for disseminated Histoplasma capsulatum and died.",
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AU - Stroup, Jeffrey

AU - Stephens, Johnny

AU - Baker, Damon

AU - Lad, Madhuri

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N2 - Amphotericin B (AmB) is commonly used in patients with a human immunodeficiency virus (HIV)-positive diagnosis for the treatment of disseminated fungal infections such as Histoplasma spp. or Cryptococcus spp. Newer liposomal formulations of AmB have been introduced to the market to avoid the toxic effects of the traditional agent. With the introduction of these new agents, there is a risk of confusion between the agents in regards to dosing, which may lead to toxicity. We report the case of an HIV-seropositive patient who inadvertently received five times the dose of AmB deoxycholate for disseminated Histoplasma capsulatum and died.

AB - Amphotericin B (AmB) is commonly used in patients with a human immunodeficiency virus (HIV)-positive diagnosis for the treatment of disseminated fungal infections such as Histoplasma spp. or Cryptococcus spp. Newer liposomal formulations of AmB have been introduced to the market to avoid the toxic effects of the traditional agent. With the introduction of these new agents, there is a risk of confusion between the agents in regards to dosing, which may lead to toxicity. We report the case of an HIV-seropositive patient who inadvertently received five times the dose of AmB deoxycholate for disseminated Histoplasma capsulatum and died.

KW - Amphotericin B

KW - HIV

KW - Histoplasmosis

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