Abstract
We compared amphetamine-induced dopamine release in the nucleus accumbens of vole species that exhibit differing mating systems to examine potential interactions between social organization and substance abuse. We found no species or regional differences in basal extracellular dopamine, however, monogamous voles had greater and longer-lasting increases in extracellular dopamine after amphetamine treatment than did promiscuous voles. We then examined whether amphetamine-induced increase in extracellular dopamine could induce pair bonds in monogamous voles. We found that, despite increasing dopamine in the nucleus accumbens, amphetamine administration did not induce pair-bonds in male prairie voles unless the animals were pretreated to preclude D1 receptor activation, which is known to inhibit pair-bond formation. These results support suggestions that social attachment and substance abuse share a common neural substrate.
| Original language | English |
|---|---|
| Pages (from-to) | 857-866 |
| Number of pages | 10 |
| Journal | Neuroscience |
| Volume | 148 |
| Issue number | 4 |
| DOIs | |
| State | Published - 21 Sep 2007 |
Fingerprint
Keywords
- addiction
- dopamine
- mating system
- microdialysis
- nucleus accumbens
- pair-bond
Cite this
}
Amphetamine effects in microtine rodents : A comparative study using monogamous and promiscuous vole species. / Curtis, J. T.; Wang, Z.
In: Neuroscience, Vol. 148, No. 4, 21.09.2007, p. 857-866.Research output: Contribution to journal › Article
TY - JOUR
T1 - Amphetamine effects in microtine rodents
T2 - A comparative study using monogamous and promiscuous vole species
AU - Curtis, J. T.
AU - Wang, Z.
PY - 2007/9/21
Y1 - 2007/9/21
N2 - We compared amphetamine-induced dopamine release in the nucleus accumbens of vole species that exhibit differing mating systems to examine potential interactions between social organization and substance abuse. We found no species or regional differences in basal extracellular dopamine, however, monogamous voles had greater and longer-lasting increases in extracellular dopamine after amphetamine treatment than did promiscuous voles. We then examined whether amphetamine-induced increase in extracellular dopamine could induce pair bonds in monogamous voles. We found that, despite increasing dopamine in the nucleus accumbens, amphetamine administration did not induce pair-bonds in male prairie voles unless the animals were pretreated to preclude D1 receptor activation, which is known to inhibit pair-bond formation. These results support suggestions that social attachment and substance abuse share a common neural substrate.
AB - We compared amphetamine-induced dopamine release in the nucleus accumbens of vole species that exhibit differing mating systems to examine potential interactions between social organization and substance abuse. We found no species or regional differences in basal extracellular dopamine, however, monogamous voles had greater and longer-lasting increases in extracellular dopamine after amphetamine treatment than did promiscuous voles. We then examined whether amphetamine-induced increase in extracellular dopamine could induce pair bonds in monogamous voles. We found that, despite increasing dopamine in the nucleus accumbens, amphetamine administration did not induce pair-bonds in male prairie voles unless the animals were pretreated to preclude D1 receptor activation, which is known to inhibit pair-bond formation. These results support suggestions that social attachment and substance abuse share a common neural substrate.
KW - addiction
KW - dopamine
KW - mating system
KW - microdialysis
KW - nucleus accumbens
KW - pair-bond
UR - http://www.scopus.com/inward/record.url?scp=34548700126&partnerID=8YFLogxK
U2 - 10.1016/j.neuroscience.2007.07.011
DO - 10.1016/j.neuroscience.2007.07.011
M3 - Article
C2 - 17706877
AN - SCOPUS:34548700126
VL - 148
SP - 857
EP - 866
JO - Neuroscience
JF - Neuroscience
SN - 0306-4522
IS - 4
ER -