Alkaloids Purified from Aristotelia chilensis Inhibit the Human α3β4 Nicotinic Acetylcholine Receptor with Higher Potencies Compared with the Human α4β2 and α7 Subtypes

Keyphrases

• Nicotinic Acetylcholine Receptor (nAChR) 100%
• High Potency 100%
• Aristotelia chilensis 100%
• Alkaloids 100%
• Acetylcholine Receptor (AChR) 66%
• Receptor Subtypes 33%
• Receptor Selectivity 33%
• Inhibitory Activity 33%
• Ion Channels 33%
• Molecular Docking 33%
• Ca2+ Influx 33%
• Lipophilicity 33%
• Addiction Therapy 33%
• Pharmacological Activities 33%
• Agonistic 33%
• NMR Spectroscopy 33%
• Structure-activity Relationship 33%
• IC50 Value 33%
• Depression Therapy 33%
• Maquis 33%
• Natural Compounds 33%
• Docking Activity 33%
• Non-competitive Inhibitor 33%
• High Selectivity 33%
• Molecular Structure 33%
• Receptor 1 33%
• Molecular Scaffold 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Nicotinic Receptor 100%
• Cholinergic Receptor 100%
• Receptor 50%
• Natural Product 50%
• IC50 50%
• Receptor Subtype 50%
• Calcium Ion 50%
• Ion Channel 50%
• 1 (5 Isoquinolinesulfonyl) 2 Methylpiperazine 50%
• Structure Activity Relationship 50%
• Pharmacological Activity 50%
• Lipophilicity 50%
• Molecular Scaffold 50%