Age- and dose-dependent effects of neonatal monosodium glutamate (MSG) administration to female rats

R. Dawson, J. W. Simpkins, David Wallace

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The age- and dose-dependent effects of neonatal MSG were evaluated in pre- and postpubertal female rats. The neurotoxic action of MSG was assessed by examining monoamine content in microdissected regions of the mediobasal hypothalamus. MSG was administered at a dose of 4 mg/g on postnatal days 2 and 4 (MSG-Lo) or on postnatal days 2, 4, 6 and 8 (MSG-Hi). MSG-Hi treatment significantly reduced dopamine (DA) content in the arcuate nucleus (ANH) and lateral median eminence (LME) on postnatal day 21 when compared to NaCl-injected controls. DA content relative to controls was not altered in the ANH or LME postnatal or postnatal day 60 in MSG-Hi, however, norepinephrine (NE) was significantly (p<0.05) decreased on both postnatal day 21 and 60 in the LME. MSG-Lo treatment significantly (p<0.05) reduced ANH NE content on postnatal day 60 compared to controls. Both MSG-Hi and MSG-Lo treatment increased 5-hydroxyindoleacetic acid content in the preoptic area (POA) on postnatal day 60 relative to the controls. Developmental changes independent of MSG treatment were noted in the hypothalamus. DA and 3,4-dihydroxyphenylacetic acid (DOPAC) content in the POA were 2-3-fold higher on postnatal day 21 compared to postnatal day 60. In contrast, DA content increased with age in the ANH, LME and medial ME. NE content in the ANH increased as a function of age in controls, but not in MSG-treated rats. The effects of MSG treatment on the postnatal development and maturation of neurons in the mediobasal hypothalamus were discussed in relation to the direct neurotoxicity of MSG.

Original languageEnglish
Pages (from-to)331-337
Number of pages7
JournalNeurotoxicology and Teratology
Volume11
Issue number4
DOIs
StatePublished - 1 Jan 1989

Fingerprint

Sodium Glutamate
Rats
Median Eminence
Dopamine
Hypothalamus
Norepinephrine
Preoptic Area
3,4-Dihydroxyphenylacetic Acid
Arcuate Nucleus of Hypothalamus
Hydroxyindoleacetic Acid
Neurons

Keywords

  • Arcuate nucleus
  • Developmental neurochemistry
  • Dopamine
  • Excitotoxin
  • Median eminence
  • Monosodium glutamate

Cite this

@article{dd432a2fa0444464a621cfc680684643,
title = "Age- and dose-dependent effects of neonatal monosodium glutamate (MSG) administration to female rats",
abstract = "The age- and dose-dependent effects of neonatal MSG were evaluated in pre- and postpubertal female rats. The neurotoxic action of MSG was assessed by examining monoamine content in microdissected regions of the mediobasal hypothalamus. MSG was administered at a dose of 4 mg/g on postnatal days 2 and 4 (MSG-Lo) or on postnatal days 2, 4, 6 and 8 (MSG-Hi). MSG-Hi treatment significantly reduced dopamine (DA) content in the arcuate nucleus (ANH) and lateral median eminence (LME) on postnatal day 21 when compared to NaCl-injected controls. DA content relative to controls was not altered in the ANH or LME postnatal or postnatal day 60 in MSG-Hi, however, norepinephrine (NE) was significantly (p<0.05) decreased on both postnatal day 21 and 60 in the LME. MSG-Lo treatment significantly (p<0.05) reduced ANH NE content on postnatal day 60 compared to controls. Both MSG-Hi and MSG-Lo treatment increased 5-hydroxyindoleacetic acid content in the preoptic area (POA) on postnatal day 60 relative to the controls. Developmental changes independent of MSG treatment were noted in the hypothalamus. DA and 3,4-dihydroxyphenylacetic acid (DOPAC) content in the POA were 2-3-fold higher on postnatal day 21 compared to postnatal day 60. In contrast, DA content increased with age in the ANH, LME and medial ME. NE content in the ANH increased as a function of age in controls, but not in MSG-treated rats. The effects of MSG treatment on the postnatal development and maturation of neurons in the mediobasal hypothalamus were discussed in relation to the direct neurotoxicity of MSG.",
keywords = "Arcuate nucleus, Developmental neurochemistry, Dopamine, Excitotoxin, Median eminence, Monosodium glutamate",
author = "R. Dawson and Simpkins, {J. W.} and David Wallace",
year = "1989",
month = "1",
day = "1",
doi = "10.1016/0892-0362(89)90003-2",
language = "English",
volume = "11",
pages = "331--337",
journal = "Neurotoxicology and Teratology",
issn = "0892-0362",
publisher = "Elsevier Inc.",
number = "4",

}

Age- and dose-dependent effects of neonatal monosodium glutamate (MSG) administration to female rats. / Dawson, R.; Simpkins, J. W.; Wallace, David.

In: Neurotoxicology and Teratology, Vol. 11, No. 4, 01.01.1989, p. 331-337.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Age- and dose-dependent effects of neonatal monosodium glutamate (MSG) administration to female rats

AU - Dawson, R.

AU - Simpkins, J. W.

AU - Wallace, David

PY - 1989/1/1

Y1 - 1989/1/1

N2 - The age- and dose-dependent effects of neonatal MSG were evaluated in pre- and postpubertal female rats. The neurotoxic action of MSG was assessed by examining monoamine content in microdissected regions of the mediobasal hypothalamus. MSG was administered at a dose of 4 mg/g on postnatal days 2 and 4 (MSG-Lo) or on postnatal days 2, 4, 6 and 8 (MSG-Hi). MSG-Hi treatment significantly reduced dopamine (DA) content in the arcuate nucleus (ANH) and lateral median eminence (LME) on postnatal day 21 when compared to NaCl-injected controls. DA content relative to controls was not altered in the ANH or LME postnatal or postnatal day 60 in MSG-Hi, however, norepinephrine (NE) was significantly (p<0.05) decreased on both postnatal day 21 and 60 in the LME. MSG-Lo treatment significantly (p<0.05) reduced ANH NE content on postnatal day 60 compared to controls. Both MSG-Hi and MSG-Lo treatment increased 5-hydroxyindoleacetic acid content in the preoptic area (POA) on postnatal day 60 relative to the controls. Developmental changes independent of MSG treatment were noted in the hypothalamus. DA and 3,4-dihydroxyphenylacetic acid (DOPAC) content in the POA were 2-3-fold higher on postnatal day 21 compared to postnatal day 60. In contrast, DA content increased with age in the ANH, LME and medial ME. NE content in the ANH increased as a function of age in controls, but not in MSG-treated rats. The effects of MSG treatment on the postnatal development and maturation of neurons in the mediobasal hypothalamus were discussed in relation to the direct neurotoxicity of MSG.

AB - The age- and dose-dependent effects of neonatal MSG were evaluated in pre- and postpubertal female rats. The neurotoxic action of MSG was assessed by examining monoamine content in microdissected regions of the mediobasal hypothalamus. MSG was administered at a dose of 4 mg/g on postnatal days 2 and 4 (MSG-Lo) or on postnatal days 2, 4, 6 and 8 (MSG-Hi). MSG-Hi treatment significantly reduced dopamine (DA) content in the arcuate nucleus (ANH) and lateral median eminence (LME) on postnatal day 21 when compared to NaCl-injected controls. DA content relative to controls was not altered in the ANH or LME postnatal or postnatal day 60 in MSG-Hi, however, norepinephrine (NE) was significantly (p<0.05) decreased on both postnatal day 21 and 60 in the LME. MSG-Lo treatment significantly (p<0.05) reduced ANH NE content on postnatal day 60 compared to controls. Both MSG-Hi and MSG-Lo treatment increased 5-hydroxyindoleacetic acid content in the preoptic area (POA) on postnatal day 60 relative to the controls. Developmental changes independent of MSG treatment were noted in the hypothalamus. DA and 3,4-dihydroxyphenylacetic acid (DOPAC) content in the POA were 2-3-fold higher on postnatal day 21 compared to postnatal day 60. In contrast, DA content increased with age in the ANH, LME and medial ME. NE content in the ANH increased as a function of age in controls, but not in MSG-treated rats. The effects of MSG treatment on the postnatal development and maturation of neurons in the mediobasal hypothalamus were discussed in relation to the direct neurotoxicity of MSG.

KW - Arcuate nucleus

KW - Developmental neurochemistry

KW - Dopamine

KW - Excitotoxin

KW - Median eminence

KW - Monosodium glutamate

UR - http://www.scopus.com/inward/record.url?scp=0024447554&partnerID=8YFLogxK

U2 - 10.1016/0892-0362(89)90003-2

DO - 10.1016/0892-0362(89)90003-2

M3 - Article

C2 - 2796887

AN - SCOPUS:0024447554

VL - 11

SP - 331

EP - 337

JO - Neurotoxicology and Teratology

JF - Neurotoxicology and Teratology

SN - 0892-0362

IS - 4

ER -