TY - JOUR
T1 - Acetylcholine stimulation of selective increases in stearic and arachidonic acids in phosphatidic acid in mouse pancreas
AU - Geison, Ronald L.
AU - Banschbach, Martin W.
AU - Sadeghian, Kenneth
AU - Hokin-Neaverson, Mabel
PY - 1976/1/26
Y1 - 1976/1/26
N2 - During the acetylcholine-stimulated loss of phosphatidylinositol and gain in the level of phosphatidic acid in mouse pancreas, there is a selective increase in stearic and arachidonic acids in phosphatidic acid. The amounts parallel the decrease in phosphatidylinositol, which contains predominantly these two fatty acids. Addition of atropine to stimulated tissue reverses the changes. There is a selective disappearance of the stearoyl, arachidonoyl phosphatidic acid, and phosphatidylinositol increases. The changes support the hypothesis that the 1-stearoyl, 2-arachidonoyl diglyceride backbone of phosphatidylinositol becomes phosphatidic acid during acetylcholine stimulation, and is transformed back to phosphatidylinositol on reversion to the unstimulated state.
AB - During the acetylcholine-stimulated loss of phosphatidylinositol and gain in the level of phosphatidic acid in mouse pancreas, there is a selective increase in stearic and arachidonic acids in phosphatidic acid. The amounts parallel the decrease in phosphatidylinositol, which contains predominantly these two fatty acids. Addition of atropine to stimulated tissue reverses the changes. There is a selective disappearance of the stearoyl, arachidonoyl phosphatidic acid, and phosphatidylinositol increases. The changes support the hypothesis that the 1-stearoyl, 2-arachidonoyl diglyceride backbone of phosphatidylinositol becomes phosphatidic acid during acetylcholine stimulation, and is transformed back to phosphatidylinositol on reversion to the unstimulated state.
UR - http://www.scopus.com/inward/record.url?scp=0017231462&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(76)91149-9
DO - 10.1016/0006-291X(76)91149-9
M3 - Article
C2 - 1252231
AN - SCOPUS:0017231462
SN - 0006-291X
VL - 68
SP - 343
EP - 349
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -