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Acetamiprid belongs to the chloronicotinyl neonicotinoid, class of insecticide. Acetamiprid exhibits greater agonistic potency at insect nicotinic acetylcholine receptors compared to mammals. The predominant use for acetamiprid is to control insects that damage leafy plants. It is available as ready-to-use, wettable powder, or water-dispersible granules. Other neonicotinoids (imidacloprid) undergo biotransformation in rodents resulting in a metabolite with higher affinity for the nicotinic receptor compared to (−)-nicotine itself, increasing the chance for toxicity in mammals. Currently, acetamiprid has not demonstrated biotransformation to a toxic metabolite, but recently it was shown that acetamiprid undergoes transepithelial absorption across intestinal cells, potentially resulting in acetamiprid accumulation in the body. Overall, the general belief is that acetamiprid presents low hazard risks to human/vertebrate populations under normal conditions. In situations of high bioaccumulation, toxicity to wildlife may be evident.

Original languageEnglish
Title of host publicationEncyclopedia of Toxicology, Fourth Edition
Subtitle of host publicationVolume 1-9
ISBN (Electronic)9780128243152
StatePublished - 1 Jan 2023


  • Bioaccumulation
  • Biotransformation
  • Chloronicotinyl
  • Honeybees
  • Insecticide
  • Neonicotinoid
  • Nicotinic acetylcholine receptor


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