A morphologic study of live Escherichia coli organism shock in baboons

J. J. Coalson, L. T. Archer, Bruce Benjamin, B. K. Beller-Todd, L. B. Hinshaw

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This study was designed to examine the response of the baboon during a 24 hr period following live Escherichia coli organism infusion. Experiments were performed on 10 young adult adolescent baboons. Eight of the baboons received a mean concentration of 1.5 × 1010 organisms/kg infused during a 30 to 360 min period. Two control baboons received anesthesia and 0.9% sodium chloride solution during the 24 hr period. Heart, lung, liver, and kidney were evaluated with both light and electron microscopy and the morphologic data were interrelated with the physiologic data. The acute lung lesion seen in 2 to 6 hr studies was not found in this prolonged shock model. Both the liver and kidney exhibited dysfunction; these pathophysiologic alterations were accompanied by morphologic changes. Sinusoidal fibrin thrombi and hepatocyte damage were observed in the liver, and were associated with increases in LDH, FLDH, and hypoglycemia. Glomerular fibrin thrombi and tubular epithelial changes of cytoplasmic vacuolization and brush border loss were present in the kidney, and an increase in BUN levels was noted. Our data would indicate that the live E. coli infusion baboon model shows pathologic and physiologic derangements quite similar to those reported in the patient in septic shock.

Original languageEnglish
Pages (from-to)10-22
Number of pages13
JournalExperimental and Molecular Pathology
Volume31
Issue number1
DOIs
StatePublished - 1 Jan 1979

Fingerprint

Papio
Liver
Escherichia coli
Shock
Fibrin
Kidney
Brushes
Sodium Chloride
Thrombosis
Electron microscopy
Optical microscopy
Lung
Blood Urea Nitrogen
Septic Shock
Microvilli
Hypoglycemia
Young Adult
Hepatocytes
Electron Microscopy
Anesthesia

Cite this

Coalson, J. J. ; Archer, L. T. ; Benjamin, Bruce ; Beller-Todd, B. K. ; Hinshaw, L. B. / A morphologic study of live Escherichia coli organism shock in baboons. In: Experimental and Molecular Pathology. 1979 ; Vol. 31, No. 1. pp. 10-22.
@article{84a75c0acc2b4905af666a83c74ad580,
title = "A morphologic study of live Escherichia coli organism shock in baboons",
abstract = "This study was designed to examine the response of the baboon during a 24 hr period following live Escherichia coli organism infusion. Experiments were performed on 10 young adult adolescent baboons. Eight of the baboons received a mean concentration of 1.5 × 1010 organisms/kg infused during a 30 to 360 min period. Two control baboons received anesthesia and 0.9{\%} sodium chloride solution during the 24 hr period. Heart, lung, liver, and kidney were evaluated with both light and electron microscopy and the morphologic data were interrelated with the physiologic data. The acute lung lesion seen in 2 to 6 hr studies was not found in this prolonged shock model. Both the liver and kidney exhibited dysfunction; these pathophysiologic alterations were accompanied by morphologic changes. Sinusoidal fibrin thrombi and hepatocyte damage were observed in the liver, and were associated with increases in LDH, FLDH, and hypoglycemia. Glomerular fibrin thrombi and tubular epithelial changes of cytoplasmic vacuolization and brush border loss were present in the kidney, and an increase in BUN levels was noted. Our data would indicate that the live E. coli infusion baboon model shows pathologic and physiologic derangements quite similar to those reported in the patient in septic shock.",
author = "Coalson, {J. J.} and Archer, {L. T.} and Bruce Benjamin and Beller-Todd, {B. K.} and Hinshaw, {L. B.}",
year = "1979",
month = "1",
day = "1",
doi = "10.1016/0014-4800(79)90003-0",
language = "English",
volume = "31",
pages = "10--22",
journal = "Experimental and Molecular Pathology",
issn = "0014-4800",
publisher = "Academic Press Inc.",
number = "1",

}

A morphologic study of live Escherichia coli organism shock in baboons. / Coalson, J. J.; Archer, L. T.; Benjamin, Bruce; Beller-Todd, B. K.; Hinshaw, L. B.

In: Experimental and Molecular Pathology, Vol. 31, No. 1, 01.01.1979, p. 10-22.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A morphologic study of live Escherichia coli organism shock in baboons

AU - Coalson, J. J.

AU - Archer, L. T.

AU - Benjamin, Bruce

AU - Beller-Todd, B. K.

AU - Hinshaw, L. B.

PY - 1979/1/1

Y1 - 1979/1/1

N2 - This study was designed to examine the response of the baboon during a 24 hr period following live Escherichia coli organism infusion. Experiments were performed on 10 young adult adolescent baboons. Eight of the baboons received a mean concentration of 1.5 × 1010 organisms/kg infused during a 30 to 360 min period. Two control baboons received anesthesia and 0.9% sodium chloride solution during the 24 hr period. Heart, lung, liver, and kidney were evaluated with both light and electron microscopy and the morphologic data were interrelated with the physiologic data. The acute lung lesion seen in 2 to 6 hr studies was not found in this prolonged shock model. Both the liver and kidney exhibited dysfunction; these pathophysiologic alterations were accompanied by morphologic changes. Sinusoidal fibrin thrombi and hepatocyte damage were observed in the liver, and were associated with increases in LDH, FLDH, and hypoglycemia. Glomerular fibrin thrombi and tubular epithelial changes of cytoplasmic vacuolization and brush border loss were present in the kidney, and an increase in BUN levels was noted. Our data would indicate that the live E. coli infusion baboon model shows pathologic and physiologic derangements quite similar to those reported in the patient in septic shock.

AB - This study was designed to examine the response of the baboon during a 24 hr period following live Escherichia coli organism infusion. Experiments were performed on 10 young adult adolescent baboons. Eight of the baboons received a mean concentration of 1.5 × 1010 organisms/kg infused during a 30 to 360 min period. Two control baboons received anesthesia and 0.9% sodium chloride solution during the 24 hr period. Heart, lung, liver, and kidney were evaluated with both light and electron microscopy and the morphologic data were interrelated with the physiologic data. The acute lung lesion seen in 2 to 6 hr studies was not found in this prolonged shock model. Both the liver and kidney exhibited dysfunction; these pathophysiologic alterations were accompanied by morphologic changes. Sinusoidal fibrin thrombi and hepatocyte damage were observed in the liver, and were associated with increases in LDH, FLDH, and hypoglycemia. Glomerular fibrin thrombi and tubular epithelial changes of cytoplasmic vacuolization and brush border loss were present in the kidney, and an increase in BUN levels was noted. Our data would indicate that the live E. coli infusion baboon model shows pathologic and physiologic derangements quite similar to those reported in the patient in septic shock.

UR - http://www.scopus.com/inward/record.url?scp=0018706021&partnerID=8YFLogxK

U2 - 10.1016/0014-4800(79)90003-0

DO - 10.1016/0014-4800(79)90003-0

M3 - Article

C2 - 110615

AN - SCOPUS:0018706021

VL - 31

SP - 10

EP - 22

JO - Experimental and Molecular Pathology

JF - Experimental and Molecular Pathology

SN - 0014-4800

IS - 1

ER -