A critical role for nucleus accumbens dopamine in partner-preference formation in male prairie voles

Brandon J. Aragona, Yan Liu, Tom Curtis, Friedrich K. Stephan, Zuoxin Wang

Research output: Contribution to journalArticle

215 Citations (Scopus)

Abstract

Although the role of nucleus accumbens (NAcc) dopamine (DA) in reward learning has been extensively studied, few investigations have addressed its involvement in learning socially relevant information. Here, we have examined the involvement of NAcc DA in social attachment of the "monogamous" prairie vole (Microtus orchrogaster). We first demonstrated that DA is necessary for the formation of social attachment in male prairie voles, because administration of haloperidol blocked, whereas apomorphine induced, partner-preference formation. We then provided the first descriptions of DA neuroanatomy and tissue content in vole NAcc, and mating appeared to induce a 33% increase in DA turnover. We also showed that administration of haloperidol directly into the NAcc blocked partner preferences induced by mating and apomorphine. In addition, administration of apomorphine into the NAcc but not the caudate putamen induced partner preferences in the absence of mating. Together, our data support the hypothesis that NAcc DA is critical for pair-bond formation in male prairie voles.

Original languageEnglish
Pages (from-to)3483-3490
Number of pages8
JournalJournal of Neuroscience
Volume23
Issue number8
StatePublished - 15 Apr 2003

Fingerprint

Arvicolinae
Nucleus Accumbens
Dopamine
Apomorphine
Haloperidol
Pair Bond
Learning
Neuroanatomy
Putamen
Reward
Grassland

Keywords

  • Apomorphine
  • Dopamine
  • Dopamine transporter
  • Haloperidol
  • Mating
  • Nucleus accumbens
  • Pair bonding
  • Tyrosine hydroxylase

Cite this

Aragona, Brandon J. ; Liu, Yan ; Curtis, Tom ; Stephan, Friedrich K. ; Wang, Zuoxin. / A critical role for nucleus accumbens dopamine in partner-preference formation in male prairie voles. In: Journal of Neuroscience. 2003 ; Vol. 23, No. 8. pp. 3483-3490.
@article{c84fbd5b19f549509f752fcc9a61348d,
title = "A critical role for nucleus accumbens dopamine in partner-preference formation in male prairie voles",
abstract = "Although the role of nucleus accumbens (NAcc) dopamine (DA) in reward learning has been extensively studied, few investigations have addressed its involvement in learning socially relevant information. Here, we have examined the involvement of NAcc DA in social attachment of the {"}monogamous{"} prairie vole (Microtus orchrogaster). We first demonstrated that DA is necessary for the formation of social attachment in male prairie voles, because administration of haloperidol blocked, whereas apomorphine induced, partner-preference formation. We then provided the first descriptions of DA neuroanatomy and tissue content in vole NAcc, and mating appeared to induce a 33{\%} increase in DA turnover. We also showed that administration of haloperidol directly into the NAcc blocked partner preferences induced by mating and apomorphine. In addition, administration of apomorphine into the NAcc but not the caudate putamen induced partner preferences in the absence of mating. Together, our data support the hypothesis that NAcc DA is critical for pair-bond formation in male prairie voles.",
keywords = "Apomorphine, Dopamine, Dopamine transporter, Haloperidol, Mating, Nucleus accumbens, Pair bonding, Tyrosine hydroxylase",
author = "Aragona, {Brandon J.} and Yan Liu and Tom Curtis and Stephan, {Friedrich K.} and Zuoxin Wang",
year = "2003",
month = "4",
day = "15",
language = "English",
volume = "23",
pages = "3483--3490",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "8",

}

A critical role for nucleus accumbens dopamine in partner-preference formation in male prairie voles. / Aragona, Brandon J.; Liu, Yan; Curtis, Tom; Stephan, Friedrich K.; Wang, Zuoxin.

In: Journal of Neuroscience, Vol. 23, No. 8, 15.04.2003, p. 3483-3490.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A critical role for nucleus accumbens dopamine in partner-preference formation in male prairie voles

AU - Aragona, Brandon J.

AU - Liu, Yan

AU - Curtis, Tom

AU - Stephan, Friedrich K.

AU - Wang, Zuoxin

PY - 2003/4/15

Y1 - 2003/4/15

N2 - Although the role of nucleus accumbens (NAcc) dopamine (DA) in reward learning has been extensively studied, few investigations have addressed its involvement in learning socially relevant information. Here, we have examined the involvement of NAcc DA in social attachment of the "monogamous" prairie vole (Microtus orchrogaster). We first demonstrated that DA is necessary for the formation of social attachment in male prairie voles, because administration of haloperidol blocked, whereas apomorphine induced, partner-preference formation. We then provided the first descriptions of DA neuroanatomy and tissue content in vole NAcc, and mating appeared to induce a 33% increase in DA turnover. We also showed that administration of haloperidol directly into the NAcc blocked partner preferences induced by mating and apomorphine. In addition, administration of apomorphine into the NAcc but not the caudate putamen induced partner preferences in the absence of mating. Together, our data support the hypothesis that NAcc DA is critical for pair-bond formation in male prairie voles.

AB - Although the role of nucleus accumbens (NAcc) dopamine (DA) in reward learning has been extensively studied, few investigations have addressed its involvement in learning socially relevant information. Here, we have examined the involvement of NAcc DA in social attachment of the "monogamous" prairie vole (Microtus orchrogaster). We first demonstrated that DA is necessary for the formation of social attachment in male prairie voles, because administration of haloperidol blocked, whereas apomorphine induced, partner-preference formation. We then provided the first descriptions of DA neuroanatomy and tissue content in vole NAcc, and mating appeared to induce a 33% increase in DA turnover. We also showed that administration of haloperidol directly into the NAcc blocked partner preferences induced by mating and apomorphine. In addition, administration of apomorphine into the NAcc but not the caudate putamen induced partner preferences in the absence of mating. Together, our data support the hypothesis that NAcc DA is critical for pair-bond formation in male prairie voles.

KW - Apomorphine

KW - Dopamine

KW - Dopamine transporter

KW - Haloperidol

KW - Mating

KW - Nucleus accumbens

KW - Pair bonding

KW - Tyrosine hydroxylase

UR - http://www.scopus.com/inward/record.url?scp=0038672171&partnerID=8YFLogxK

M3 - Article

C2 - 12716957

AN - SCOPUS:0038672171

VL - 23

SP - 3483

EP - 3490

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 8

ER -