A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals

Diana Herrera-Perez, Alyson Haslam, Tyler Crain, Jennifer Gill, Catherine Livingston, Victoria Kaestner, Michael Hayes, Dan Morgan, Adam S. Cifu, Vinay Prasad

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The ability to identify medical reversals and other low-value medical practices is an essential prerequisite for efforts to reduce spending on such practices. Through an analysis of more than 3000 randomized controlled trials (RCTs) published in three leading medical journals (the Journal of the American Medical Association, the Lancet, and the New England Journal of Medicine), we have identified 396 medical reversals. Most of the studies (92%) were conducted on populations in high- income countries, cardiovascular disease was the most common medical category (20%), and medication was the most common type of intervention (33%).

Original languageEnglish
Article numbere45183
JournaleLife
Volume8
DOIs
StatePublished - 1 Jun 2019
Externally publishedYes

Fingerprint

New England
American Medical Association
Medicine
Cardiovascular Diseases
Randomized Controlled Trials

Cite this

Herrera-Perez, D., Haslam, A., Crain, T., Gill, J., Livingston, C., Kaestner, V., ... Prasad, V. (2019). A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals. eLife, 8, [e45183]. https://doi.org/10.7554/eLife.48459
Herrera-Perez, Diana ; Haslam, Alyson ; Crain, Tyler ; Gill, Jennifer ; Livingston, Catherine ; Kaestner, Victoria ; Hayes, Michael ; Morgan, Dan ; Cifu, Adam S. ; Prasad, Vinay. / A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals. In: eLife. 2019 ; Vol. 8.
@article{418efa21001a48d09d64d9d5ced90dfe,
title = "A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals",
abstract = "The ability to identify medical reversals and other low-value medical practices is an essential prerequisite for efforts to reduce spending on such practices. Through an analysis of more than 3000 randomized controlled trials (RCTs) published in three leading medical journals (the Journal of the American Medical Association, the Lancet, and the New England Journal of Medicine), we have identified 396 medical reversals. Most of the studies (92{\%}) were conducted on populations in high- income countries, cardiovascular disease was the most common medical category (20{\%}), and medication was the most common type of intervention (33{\%}).",
author = "Diana Herrera-Perez and Alyson Haslam and Tyler Crain and Jennifer Gill and Catherine Livingston and Victoria Kaestner and Michael Hayes and Dan Morgan and Cifu, {Adam S.} and Vinay Prasad",
year = "2019",
month = "6",
day = "1",
doi = "10.7554/eLife.48459",
language = "English",
volume = "8",
journal = "eLife",
issn = "2050-084X",

}

Herrera-Perez, D, Haslam, A, Crain, T, Gill, J, Livingston, C, Kaestner, V, Hayes, M, Morgan, D, Cifu, AS & Prasad, V 2019, 'A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals', eLife, vol. 8, e45183. https://doi.org/10.7554/eLife.48459

A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals. / Herrera-Perez, Diana; Haslam, Alyson; Crain, Tyler; Gill, Jennifer; Livingston, Catherine; Kaestner, Victoria; Hayes, Michael; Morgan, Dan; Cifu, Adam S.; Prasad, Vinay.

In: eLife, Vol. 8, e45183, 01.06.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals

AU - Herrera-Perez, Diana

AU - Haslam, Alyson

AU - Crain, Tyler

AU - Gill, Jennifer

AU - Livingston, Catherine

AU - Kaestner, Victoria

AU - Hayes, Michael

AU - Morgan, Dan

AU - Cifu, Adam S.

AU - Prasad, Vinay

PY - 2019/6/1

Y1 - 2019/6/1

N2 - The ability to identify medical reversals and other low-value medical practices is an essential prerequisite for efforts to reduce spending on such practices. Through an analysis of more than 3000 randomized controlled trials (RCTs) published in three leading medical journals (the Journal of the American Medical Association, the Lancet, and the New England Journal of Medicine), we have identified 396 medical reversals. Most of the studies (92%) were conducted on populations in high- income countries, cardiovascular disease was the most common medical category (20%), and medication was the most common type of intervention (33%).

AB - The ability to identify medical reversals and other low-value medical practices is an essential prerequisite for efforts to reduce spending on such practices. Through an analysis of more than 3000 randomized controlled trials (RCTs) published in three leading medical journals (the Journal of the American Medical Association, the Lancet, and the New England Journal of Medicine), we have identified 396 medical reversals. Most of the studies (92%) were conducted on populations in high- income countries, cardiovascular disease was the most common medical category (20%), and medication was the most common type of intervention (33%).

UR - http://www.scopus.com/inward/record.url?scp=85067789782&partnerID=8YFLogxK

U2 - 10.7554/eLife.48459

DO - 10.7554/eLife.48459

M3 - Article

C2 - 31182188

AN - SCOPUS:85067789782

VL - 8

JO - eLife

JF - eLife

SN - 2050-084X

M1 - e45183

ER -