A 44-year-old woman with hematemesis and cutaneous hemorrhages as a result of superwarfarin poisoning

Elizabeth K. Dolin, Damon L. Baker, Steven C. Buck

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The authors present the case of a 44-year-old American Indian woman with hematemesis, spontaneous cutaneous hemorrhages, and multiple ecchymoses. Coagulation factor analyses demonstrated both prolonged prothrombin time (PT, >40 s) and prolonged partial thromboplastin time (PTT, >120 s). Measurement of the serum level of brodifacoum (37 ng/mL), one of the superwarfarin agents commonly used in rodenticides, confirmed poisoning as the cause of the patient's symptoms. Substantial amounts of fresh frozen plasma and vitamin K were required to obtain normal coagulation parameters and maintain these parameters over a 3-week inhospital period. Oral administration of vitamin K (100 mg daily) maintained normal PT (14.1 s), PTT (33.0 s), and international normalized ratio (INR, 1.48) at 2 weeks after the patient was discharged from the hospital. By 2 months postdischarge, PT, PTT, and INR returned to elevated levels because of patient noncompliance with the prescribed tapering vitamin K regimen.

Original languageEnglish
Pages (from-to)280-284
Number of pages5
JournalJournal of the American Osteopathic Association
Volume106
Issue number5
StatePublished - 1 May 2006

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