W. Kyle Simmons, PhD

Director, Oklahoma State University Biomedical Imaging Center, and Associate Professor of Pharmacology and Physiology

  • 6437 Citations
  • 31 h-Index
20032020

Research output per year

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Research Output

2020

Appetite change profiles in depression exhibit differential relationships between systemic inflammation and activity in reward and interoceptive neurocircuitry

Cosgrove, K. T., Burrows, K., Avery, J. A., Kerr, K. L., DeVille, D. C., Aupperle, R. L., Teague, T. K., Drevets, W. C. & Simmons, W. K., Jan 2020, In : Brain, Behavior, and Immunity. 83, p. 163-171 9 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Corrigendum to “Always on my mind: Cross-brain associations of mental health symptoms during simultaneous parent-child scanning” [Dev. Cognit. Neurosci. 40 (December) (2019) 100729](S1878929319303160)(10.1016/j.dcn.2019.100729)

Cosgrove, K. T., Kerr, K. L., Aupperle, R. L., Ratliff, E. L., DeVille, D. C., Silk, J. S., Burrows, K., Moore, A. J., Antonacci, C., Misaki, M., Tapert, S. F., Bodurka, J., Simmons, W. K. & Morris, A. S., Feb 2020, In : Developmental Cognitive Neuroscience. 41, 100751.

Research output: Contribution to journalComment/debate

Open Access

TEAMwork: Testing Emotional Attunement and Mutuality During Parent-Adolescent fMRI

Kerr, K. L., Cosgrove, K. T., Ratliff, E. L., Burrows, K., Misaki, M., Moore, A. J., DeVille, D. C., Silk, J. S., Tapert, S. F., Bodurka, J., Simmons, W. K. & Morris, A. S., 7 Feb 2020, In : Frontiers in Human Neuroscience. 14, 24.

Research output: Contribution to journalArticle

Open Access
2019

Always on my mind: Cross-brain associations of mental health symptoms during simultaneous parent-child scanning

Cosgrove, K. T., Kerr, K. L., Aupperle, R. L., Ratliff, E. L., DeVille, D. C., Silk, J. S., Burrows, K., Moore, A. J., Antonacci, C., Misaki, M., Tapert, S. F., Bodurka, J., Simmons, W. K. & Morris, A. S., Dec 2019, In : Developmental Cognitive Neuroscience. 40, 100729.

Research output: Contribution to journalArticle

Open Access

Depression and obesity: evidence of shared biological mechanisms

Milaneschi, Y., Simmons, W. K., van Rossum, E. F. C. & Penninx, B. W., 1 Jan 2019, In : Molecular Psychiatry. 24, 1, p. 18-33 16 p.

Research output: Contribution to journalReview article

68 Scopus citations

Image processing and analysis methods for the Adolescent Brain Cognitive Development Study

Hagler, D. J., Hatton, S. N., Cornejo, M. D., Makowski, C., Fair, D. A., Dick, A. S., Sutherland, M. T., Casey, B. J., Barch, D. M., Harms, M. P., Watts, R., Bjork, J. M., Garavan, H. P., Hilmer, L., Pung, C. J., Sicat, C. S., Kuperman, J., Bartsch, H., Xue, F., Heitzeg, M. M. & 123 others, Laird, A. R., Trinh, T. T., Gonzalez, R., Tapert, S. F., Riedel, M. C., Squeglia, L. M., Hyde, L. W., Rosenberg, M. D., Earl, E. A., Howlett, K. D., Baker, F. C., Soules, M., Diaz, J., de Leon, O. R., Thompson, W. K., Neale, M. C., Herting, M., Sowell, E. R., Alvarez, R. P., Hawes, S. W., Sanchez, M., Bodurka, J., Breslin, F. J., Morris, A. S., Paulus, M. P., Simmons, W. K., Polimeni, J. R., van der Kouwe, A., Nencka, A. S., Gray, K. M., Pierpaoli, C., Matochik, J. A., Noronha, A., Aklin, W. M., Conway, K., Glantz, M., Hoffman, E., Little, R., Lopez, M., Pariyadath, V., Weiss, S. RB., Wolff-Hughes, D. L., DelCarmen-Wiggins, R., Feldstein Ewing, S. W., Miranda-Dominguez, O., Nagel, B. J., Perrone, A. J., Sturgeon, D. T., Goldstone, A., Pfefferbaum, A., Pohl, K. M., Prouty, D., Uban, K., Bookheimer, S. Y., Dapretto, M., Galvan, A., Bagot, K., Giedd, J., Infante, M. A., Jacobus, J., Patrick, K., Shilling, P. D., Desikan, R., Li, Y., Sugrue, L., Banich, M. T., Friedman, N., Hewitt, J. K., Hopfer, C., Sakai, J., Tanabe, J., Cottler, L. B., Nixon, S. J., Chang, L., Cloak, C., Ernst, T., Reeves, G., Kennedy, D. N., Heeringa, S., Peltier, S., Schulenberg, J., Sripada, C., Zucker, R. A., Iacono, W. G., Luciana, M., Calabro, F. J., Clark, D. B., Lewis, D. A., Luna, B., Schirda, C., Brima, T., Foxe, J. J., Freedman, E. G., Mruzek, D. W., Mason, M. J., Huber, R., McGlade, E., Prescot, A., Renshaw, P. F., Yurgelun-Todd, D. A., Allgaier, N. A., Dumas, J. A., Ivanova, M., Potter, A., Florsheim, P., Larson, C., Lisdahl, K., Charness, M. E., Fuemmeler, B., Hettema, J. M., Maes, H. H., Steinberg, J., Anokhin, A. P., Glaser, P., Heath, A. C., Madden, P. A., Baskin-Sommers, A., Constable, R. T., Grant, S. J., Dowling, G. J., Brown, S. A., Jernigan, T. L. & Dale, A. M., 15 Nov 2019, In : NeuroImage. 202, 116091.

Research output: Contribution to journalArticle

26 Scopus citations
2018

Appetite changes reveal depression subgroups with distinct endocrine, metabolic, and immune states

Simmons, W. K., Burrows, K., Avery, J. A., Kerr, K. L., Taylor, A., Bodurka, J., Potter, W., Teague, T. K. & Drevets, W. C., 13 Jun 2018, (Accepted/In press) In : Molecular Psychiatry. 25, 7, p. 1-12 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Cardiorespiratory noise correction improves the ASL signal

Hassanpour, M. S., Luo, Q., Simmons, W. K., Feinstein, J. S., Paulus, M. P., Luh, W. M., Bodurka, J. & Khalsa, S. S., Jun 2018, In : Human Brain Mapping. 39, 6, p. 2353-2367 15 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Effect of Ibuprofen on BrainAGE: A Randomized, Placebo-Controlled, Dose-Response Exploratory Study

Le, T. T., Kuplicki, R., Yeh, H. W., Aupperle, R. L., Khalsa, S. S., Simmons, W. K. & Paulus, M. P., Oct 2018, In : Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 3, 10, p. 836-843 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Examining the short-term anxiolytic and antidepressant effect of Floatation-REST

Feinstein, J. S., Khalsa, S. S., Yeh, H. W., Wohlrab, C., Simmons, W. K., Stein, M. B. & Paulus, M. P., Feb 2018, In : PLoS ONE. 13, 2, e0190292.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Interoception and Mental Health: A Roadmap

Interoception Summit 2016 participants, Jun 2018, In : Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 3, 6, p. 501-513 13 p.

Research output: Contribution to journalReview article

133 Scopus citations

Learning situated emotions

Lebois, L. A. M., Wilson-Mendenhall, C. D., Simmons, W. K., Barrett, L. F. & Barsalou, L. W., 1 Jan 2018, (Accepted/In press) In : Neuropsychologia. 145, 106637.

Research output: Contribution to journalArticle

3 Scopus citations

Neural correlates of taste reactivity in autism spectrum disorder

Avery, J. A., Ingeholm, J. E., Wohltjen, S., Collins, M., Riddell, C. D., Gotts, S. J., Kenworthy, L., Wallace, G. L., Simmons, W. K. & Martin, A., 1 Jan 2018, In : NeuroImage: Clinical. 19, p. 38-46 9 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Taking Aim at Interoception's Role in Mental Health

Khalsa, S. S., Feinstein, J. S., Simmons, W. K. & Paulus, M. P., Jun 2018, In : Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 3, 6, p. 496-498 3 p.

Research output: Contribution to journalComment/debate

5 Scopus citations

The Elicitation of Relaxation and Interoceptive Awareness Using Floatation Therapy in Individuals With High Anxiety Sensitivity

Feinstein, J. S., Khalsa, S. S., Yeh, H., Al Zoubi, O., Arevian, A. C., Wohlrab, C., Pantino, M. K., Cartmell, L. J., Simmons, W. K., Stein, M. B. & Paulus, M. P., Jun 2018, In : Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 3, 6, p. 555-562 8 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

The insular cortex dynamically maps changes in cardiorespiratory interoception

Hassanpour, M. S., Simmons, W. K., Feinstein, J. S., Luo, Q., Lapidus, R. C., Bodurka, J., Paulus, M. P. & Khalsa, S. S., 1 Jan 2018, In : Neuropsychopharmacology. 43, 2, p. 426-434 9 p.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

The Neural Bases of Interoceptive Encoding and Recall in Healthy Adults and Adults With Depression

DeVille, D. C., Kerr, K. L., Avery, J. A., Burrows, K., Bodurka, J., Feinstein, J. S., Khalsa, S. S., Paulus, M. P. & Simmons, W. K., Jun 2018, In : Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 3, 6, p. 546-554 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Tulsa 1000: A naturalistic study protocol for multilevel assessment and outcome prediction in a large psychiatric sample

Victor, T. A., Khalsa, S. S., Simmons, W. K., Feinstein, J. S., Savitz, J., Aupperle, R. L., Yeh, H. W., Bodurka, J. & Paulus, M. P., 1 Jan 2018, In : BMJ Open. 8, 1, e016620.

Research output: Contribution to journalArticle

20 Scopus citations
2017

Differential privacy-based evaporative cooling feature selection and classification with relief-F and random forests

Le, T. T., Simmons, W. K., Misaki, M., Bodurka, J., White, B. C., Savitz, J. & McKinney, B. A., 1 Jan 2017, In : Bioinformatics. 33, 18, p. 2906-2913 8 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Evidence for a large-scale brain system supporting allostasis and interoception in humans

Kleckner, I. R., Zhang, J., Touroutoglou, A., Chanes, L., Xia, C., Simmons, W. K., Quigley, K. S., Dickerson, B. C. & Feldman Barrett, L., 10 Apr 2017, In : Nature Human Behaviour. 1, 5, 0069.

Research output: Contribution to journalReview article

100 Scopus citations

How the Brain Wants What the Body Needs: The Neural Basis of Positive Alliesthesia

Avery, J. A., Burrows, K., Kerr, K. L., Bodurka, J., Khalsa, S. S., Paulus, M. P. & Simmons, W. K., 1 Mar 2017, In : Neuropsychopharmacology. 42, 4, p. 822-830 9 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Influence of Visceral Interoceptive Experience on the Brain's Response to Food Images in Anorexia Nervosa

Kerr, K. L., Moseman, S. E., Avery, J. A., Bodurka, J. & Simmons, W. K., 1 Sep 2017, In : Psychosomatic Medicine. 79, 7, p. 777-784 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Interoceptive contributions to healthy eating and obesity

Simmons, W. K. & DeVille, D. C., Oct 2017, In : Current Opinion in Psychology. 17, p. 106-112 7 p.

Research output: Contribution to journalReview article

16 Scopus citations

Obesity is associated with altered mid-insula functional connectivity to limbic regions underlying appetitive responses to foods

Avery, J. A., Powell, J. N., Breslin, F. J., Lepping, R. J., Martin, L. E., Patrician, T. M., Donnelly, J. E., Savage, C. R. & Simmons, W. K., 1 Nov 2017, In : Journal of Psychopharmacology. 31, 11, p. 1475-1484 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

PTSD and cognitive symptoms relate to inhibition-related prefrontal activation and functional connectivity

Clausen, A. N., Francisco, A. J., Thelen, J., Bruce, J., Martin, L. E., McDowd, J., Simmons, W. K. & Aupperle, R. L., May 2017, In : Depression and Anxiety. 34, 5, p. 427-436 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

The Clinical Significance of Posterior Insular Volume in Adolescent Anorexia Nervosa

Zucker, N. L., Kragel, P. A., Wagner, H. R., Keeling, L., Mayer, E., Wang, J., Kang, M. S., Merwin, R., Simmons, W. K. & LaBar, K. S., 1 Nov 2017, In : Psychosomatic Medicine. 79, 9, p. 1025-1035 11 p.

Research output: Contribution to journalArticle

3 Scopus citations
2016

Altered insula activity during visceral interoception in weight-restored patients with anorexia nervosa

Kerr, K. L., Moseman, S. E., Avery, J. A., Bodurka, J., Zucker, N. L. & Simmons, W. K., 1 Jan 2016, In : Neuropsychopharmacology. 41, 2, p. 521-528 8 p.

Research output: Contribution to journalArticle

Open Access
57 Scopus citations

Depression-related increases and decreases in appetite: Dissociable patterns of aberrant activity in reward and interoceptive neurocircuitry

Simmons, W. K., Burrows, K., Avery, J. A., Kerr, K. L., Bodurka, J., Savage, C. R. & Drevets, W. C., 1 Apr 2016, In : American Journal of Psychiatry. 173, 4, p. 418-428 11 p.

Research output: Contribution to journalArticle

Open Access
59 Scopus citations

Neural processing of emotional musical and nonmusical stimuli in depression

Lepping, R. J., Atchley, R. A., Chrysikou, E., Martin, L. E., Clair, A. A., Ingram, R. E., Simmons, W. K. & Savage, C. R., Jun 2016, In : PLoS ONE. 11, 6, e0156859.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations
2015

A common gustatory and interoceptive representation in the human mid-insula

Avery, J. A., Kerr, K. L., Ingeholm, J. E., Burrows, K., Bodurka, J. & Simmons, W. K., 1 Jan 2015, In : Human Brain Mapping. 36, 8, p. 2996-3006 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

A preliminary study of self-reported food selectivity in adolescents and young adults with autism spectrum disorder

Kuschner, E. S., Eisenberg, I. W., Orionzi, B., Simmons, W. K., Kenworthy, L., Martin, A. & Wallace, G. L., 1 Jul 2015, In : Research in Autism Spectrum Disorders. 15-16, p. 53-59 7 p., 1037.

Research output: Contribution to journalArticle

30 Scopus citations

Attentional bias to food cues in youth with loss of control eating

Shank, L. M., Tanofsky-Kraff, M., Nelson, E. E., Shomaker, L. B., Ranzenhofer, L. M., Hannallah, L. M., Field, S. E., Vannucci, A., Bongiorno, D. M., Brady, S. M., Condarco, T., Demidowich, A., Kelly, N. R., Cassidy, O., Simmons, W. K., Engel, S. G., Pine, D. S. & Yanovski, J. A., 1 Apr 2015, In : Appetite. 87, p. 68-75 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Interoceptive predictions in the brain

Barrett, L. F. & Simmons, W. K., 22 Jul 2015, In : Nature Reviews Neuroscience. 16, 7, p. 419-429 11 p.

Research output: Contribution to journalReview article

435 Scopus citations

Methodological recommendations for a heartbeat detection-based measure of interoceptive sensitivity

Kleckner, I. R., Wormwood, J. B., Simmons, W. K., Barrett, L. F. & Quigley, K. S., 1 Nov 2015, In : Psychophysiology. 52, 11, p. 1432-1440 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Resting-state brain connectivity after surgical and behavioral weight loss

Lepping, R. J., Bruce, A. S., Francisco, A., Yeh, H. W., Martin, L. E., Powell, J. N., Hancock, L., Patrician, T. M., Breslin, F. J., Selim, N., Donnelly, J. E., Brooks, W. M., Savage, C. R., Simmons, W. K. & Bruce, J. M., 1 Jul 2015, In : Obesity. 23, 7, p. 1422-1428 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Trait impulsivity is related to ventral ACC and amygdala activity during primary reward anticipation

Kerr, K. L., Avery, J. A., Barcalow, J. C., Moseman, S. E., Bodurka, J., Bellgowan, P. S. F. & Simmons, W. K., Jan 2015, In : Social Cognitive and Affective Neuroscience. 10, 1, p. 36-42 7 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Using human brain imaging to map the neurocircuitry underlying food motivation

Simmons, W. K., 1 Jan 2015.

Research output: Contribution to conferencePaper

2014

Major depressive disorder is associated with abnormal interoceptive activity and functional connectivity in the insula

Avery, J. A., Drevets, W. C., Moseman, S. E., Bodurka, J., Barcalow, J. C. & Simmons, W. K., 1 Aug 2014, In : Biological Psychiatry. 76, 3, p. 258-266 9 p.

Research output: Contribution to journalArticle

173 Scopus citations

Striatal dopamine D2-like receptor correlation patterns with human obesity and opportunistic eating behavior

Guo, J., Simmons, W. K., Herscovitch, P., Martin, A. & Hall, K. D., 1 Oct 2014, In : Molecular Psychiatry. 19, 10, p. 1078-1084 7 p.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations

The ventral pallidum and orbitofrontal cortex support food pleasantness inferences

Simmons, W. K., Rapuano, K. M., Ingeholm, J. E., Avery, J., Kallman, S., Hall, K. D. & Martin, A., Mar 2014, In : Brain Structure and Function. 219, 2, p. 473-483 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Tonic hyper-connectivity of reward neurocircuitry in obese children

Black, W. R., Lepping, R. J., Bruce, A. S., Powell, J. N., Bruce, J. M., Martin, L. E., Davis, A. M., Brooks, W. M., Savage, C. R. & Simmons, W. K., 1 Jan 2014, In : Obesity. 22, 7, p. 1590-1593 4 p.

Research output: Contribution to journalArticle

23 Scopus citations
2013

Category-specific integration of homeostatic signals in caudal but not rostral human insula

Simmons, W. K., Rapuano, K. M., Kallman, S. J., Ingeholm, J. E., Miller, B., Gotts, S. J., Avery, J. A., Hall, K. D. & Martin, A., 1 Nov 2013, In : Nature Neuroscience. 16, 11, p. 1551-1552 2 p.

Research output: Contribution to journalArticle

59 Scopus citations

Contextual processing of abstract concepts reveals neural representations of nonlinguistic semantic content

Wilson-Mendenhall, C. D., Simmons, W. K., Martin, A. & Barsalou, L. W., 2013, In : Journal of Cognitive Neuroscience. 25, 6, p. 920-935 16 p.

Research output: Contribution to journalArticle

56 Scopus citations

Keeping the body in mind: Insula functional organization and functional connectivity integrate interoceptive, exteroceptive, and emotional awareness

Simmons, W. K., Avery, J. A., Barcalow, J. C., Bodurka, J., Drevets, W. C. & Bellgowan, P., 1 Nov 2013, In : Human Brain Mapping. 34, 11, p. 2944-2958 15 p.

Research output: Contribution to journalArticle

172 Scopus citations
2012

A "taste" of what is to come: Reward sensitivity as a potential endophenotype for major depressive disorder

Simmons, W. K. & Drevets, W. C., 1 Oct 2012, In : Biological Psychiatry. 72, 7, p. 526-527 2 p.

Research output: Contribution to journalComment/debate

8 Scopus citations

Fractionation of social brain circuits in autism spectrum disorders

Gotts, S. J., Simmons, W. K., Milbury, L. A., Wallace, G. L., Cox, R. W. & Martin, A., Sep 2012, In : Brain. 135, 9, p. 2711-2725 15 p.

Research output: Contribution to journalArticle

Open Access
198 Scopus citations

Language and simulation in conceptual processing

Barsalou, L. W., Santos, A., Simmons, W. K. & Wilson, C. D., 22 Mar 2012, Symbols and Embodiment: Debates on Meaning and Cognition. Oxford University Press

Research output: Chapter in Book/Report/Conference proceedingChapter

37 Scopus citations

Spontaneous resting-state BOLD fluctuations reveal persistent domain-specific neural networks

Simmons, W. K. & Martin, A., 1 Apr 2012, In : Social Cognitive and Affective Neuroscience. 7, 4, p. 467-475 9 p., nsr018.

Research output: Contribution to journalArticle

Open Access
44 Scopus citations
2011

Grounding emotion in situated conceptualization

Wilson-Mendenhall, C. D., Barrett, L. F., Simmons, W. K. & Barsalou, L. W., 1 Apr 2011, In : Neuropsychologia. 49, 5, p. 1105-1127 23 p.

Research output: Contribution to journalArticle

167 Scopus citations

Self-regulation of amygdala activation using real-time FMRI neurofeedback

Zotev, V., Krueger, F., Phillips, R., Alvarez, R. P., Simmons, W. K., Bellgowan, P., Drevets, W. C. & Bodurka, J., 8 Sep 2011, In : PLoS ONE. 6, 9, e24522.

Research output: Contribution to journalArticle

Open Access
182 Scopus citations