• 267 Citations
  • 6 h-Index
20062020

Research output per year

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Personal profile

Research Interests

Chronic inflammatory pain is the hallmark of inflammatory bowel disease including Ulcerative Colitis and Crohn’s Disease. Glutaminase (GLS), the enzyme that converts glutamine to glutamate, the excitatory neurotransmitter in sensory neurons are at the center of glutamate metabolism and has been shown to be elevated in chronic inflammatory pain. We are interested in finding different epigenetic fingerprints, which are involved in regulating this enzyme to control chronic pain in rat model of colitis.

Research Opportunities with Dr. Das

Research Area: Molecular Biology

Project Title: Epigenetic Neuroinflammation

Project Description: Epigenomics is a study of complete epigenetic markers in our genome. These modifications control the gene regulation without affecting the gene sequence. One of these modifications is DNA methylation where cytosines in CpG dinucleotides are methylated. DNA methylation of CpG dinucleotides in the promoter region generally leads to gene repression (turning off the gene). Recently, we have seen that DNA methylation also results in gene activation (turning on the genes) in colon inflammation. We are currently studying the different transcriptional activators which get modulated by DNA methylation and results in transcriptional activation. We employ different techniques like Methylation-specific PCR, Bisulfite conversion, ChiP, EMSA and other related techniques to study these epiegenetic modifications.

Currently Seeking Students: Yes

Time Commitment: 8-10 hrs/week

Possible Coauthorship: Yes

Compensation: Unpaid

Location: OSU-CHS campus

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Research Output

  • 267 Citations
  • 6 h-Index
  • 7 Article
  • 1 Review article

Separation of rat epidermis and dermis with thermolysin to detect site-specific inflammatory mRNA and protein

Gujar, V., Anderson, M., Miller, K., Pande, R. D., Nawani, P. & Das, S., 2020, (Accepted/In press) In : JoVE.

Research output: Contribution to journalArticle

  • 10 Scopus citations

    Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a

    Banerjee, S., Meng, J., Das, S., Krishnan, A., Haworth, J., Charboneau, R., Zeng, Y., Ramakrishnan, S. & Roy, S., 2013, In : Scientific Reports. 3, 1977.

    Research output: Contribution to journalArticle

    Open Access
  • 34 Scopus citations

    Pharmacological characterization of LPS and opioid interactions at the toll-like receptor 4

    Stevens, C. W., Aravind, S., Das, S. & Davis, R. L., Mar 2013, In : British Journal of Pharmacology. 168, 6, p. 1421-1429 9 p.

    Research output: Contribution to journalArticle

  • 55 Scopus citations

    β-Funaltrexamine inhibits chemokine (CXCL10) expression in normal human astrocytes

    Davis, R. L., Das, S., Buck, D. J. & Stevens, C. W., Mar 2013, In : Neurochemistry International. 62, 4, p. 478-485 8 p.

    Research output: Contribution to journalArticle

  • 4 Scopus citations