• 1205 Citations
  • 21 h-Index
1985 …2020

Research output per year

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Personal profile

Research Interests

Dr. Miller’s research effort evaluates glutamate metabolism in sensory systems during inflammatory, injury, and pain conditions and, in particular, three areas: 1. Primary sensory neurons under painful, inflammatory and neuropathic conditions. 2. Spinal processing of inflammatory nociceptive information from visceral and somatic structures. 3. Response of neurons to injury and CNS inflammation. He has two US patents (# 7,288,246; #7,504,231) and his team has expertise in enzyme and amino acid analysis (HPLC), histochemistry, quantitative immunohistochemistry, immunoblotting, ELISA, electron microscopy, qPCR, and behavioral testing.

Research Opportunities with Dr. Miller

Research Area: Neuroscience, pain, inflammation, infection

Project Title: Glutamate metabolism in sensory systems during pain, injury, and inflammatory conditions

Project Description: My research evaluates glutamate metabolism in sensory systems during pain, injury, and inflammatory conditions. The production and degradation of glutamate, major excitatory neurotransmitter, is poorly understood in the peripheral nervous system. We have made 5 discoveries regarding hypersensitivity of sensory neurons during chronic pain: 1. Glutamate (Glu) release from peripheral nerve terminals contributes to edema and sensitization. 2. During inflammation, neuronal cell bodies have a biphasic temporal alteration in production of glutaminase (GLS1) and cytosolic aspartate aminotransferase (cAST), enzymes for Glu synthesis. 3. Increased amounts of GLS1 and cAST, shipped to peripheral terminals, elevate production and release of Glu producing persistent sensitization of primary sensory neurons, i.e., increased pain. 4. Inhibition of peripheral Glu production reduces inflammation and gives pain relief. 5. Nerve growth factor (NGF), produced from the inflammatory site, is responsible for acute and long-term alterations that occur in DRG neurons.

Currently Seeking Students: Yes

Time Commitment: 8 hours per week

Possible Coauthorship: Yes

Compensation: Unpaid

Location: OSU-CHS

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Research Output

  • 1205 Citations
  • 21 h-Index
  • 50 Article
  • 1 Review article

Separation of rat epidermis and dermis with thermolysin to detect site-specific inflammatory mRNA and protein

Gujar, V., Anderson, M., Miller, K., Pande, R. D., Nawani, P. & Das, S., 2020, (Accepted/In press) In : JoVE.

Research output: Contribution to journalArticle

The Aerobic and Cognitive Exercise Study (ACES) for community-dwelling older adults with or at-risk for mild cognitive impairment (MCI): Neuropsychological, neurobiological and neuroimaging outcomes of a randomized clinical trial

Anderson-Hanley, C., Barcelos, N. M., Zimmerman, E. A., Gillen, R. W., Dunnam, M., Cohen, B. D., Yerokhin, V., Miller, K. E., Hayes, D. J., Arciero, P. J., Maloney, M. & Kramer, A. F., 4 May 2018, In : Frontiers in Aging Neuroscience. 10, MAY, 76.

Research output: Contribution to journalArticle

  • 25 Scopus citations

    Evaluation of genetic toxicity of 6-diazo-5-oxo-l-norleucine (DON)

    Kulkarni, R. M., Dakoulas, E. W., Miller, K. E. & Terse, P. S., 2 Sep 2017, In : Toxicology Mechanisms and Methods. 27, 7, p. 518-527 10 p.

    Research output: Contribution to journalArticle

  • Characterization of glutamatergic neurons in the rat atrial intrinsic cardiac ganglia that project to the cardiac ventricular wall

    Wang, T. & Miller, K. E., 4 Aug 2016, In : Neuroscience. 329, p. 134-150 17 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Glutaminase increases in rat dorsal root ganglion neurons after unilateral adjuvant-induced hind paw inflammation

    Hoffman, E. M., Zhang, Z., Schechter, R. & Miller, K. E., 13 Jan 2016, In : Biomolecules. 6, 1

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    Press / Media

    United States Post Office

    Kenneth Miller

    5/09/20

    1 item of Media coverage

    Press/Media

    Miller, Kenneth J.

    Kenneth Miller

    10/08/20

    1 item of Media coverage

    Press/Media

    Northwestern announces honor roll for spring 2020

    Kenneth Miller

    20/06/2021/06/20

    2 items of Media coverage

    Press/Media