Kenneth Miller

Personal profile

Research Interests

Dr. Miller’s research effort evaluates glutamate metabolism in sensory systems during inflammatory, injury, and pain conditions and, in particular, three areas: 1. Primary sensory neurons under painful, inflammatory and neuropathic conditions. 2. Spinal processing of inflammatory nociceptive information from visceral and somatic structures. 3. Response of neurons to injury and CNS inflammation. He has two US patents (# 7,288,246; #7,504,231) and his team has expertise in enzyme and amino acid analysis (HPLC), histochemistry, quantitative immunohistochemistry, immunoblotting, ELISA, electron microscopy, qPCR, and behavioral testing.

Research Opportunities with Dr. Miller

Research Area: Neuroscience, pain, inflammation, infection

Project Title: Glutamate metabolism in sensory systems during pain, injury, and inflammatory conditions

Project Description: My research evaluates glutamate metabolism in sensory systems during pain, injury, and inflammatory conditions. The production and degradation of glutamate, major excitatory neurotransmitter, is poorly understood in the peripheral nervous system. We have made 5 discoveries regarding hypersensitivity of sensory neurons during chronic pain: 1. Glutamate (Glu) release from peripheral nerve terminals contributes to edema and sensitization. 2. During inflammation, neuronal cell bodies have a biphasic temporal alteration in production of glutaminase (GLS1) and cytosolic aspartate aminotransferase (cAST), enzymes for Glu synthesis. 3. Increased amounts of GLS1 and cAST, shipped to peripheral terminals, elevate production and release of Glu producing persistent sensitization of primary sensory neurons, i.e., increased pain. 4. Inhibition of peripheral Glu production reduces inflammation and gives pain relief. 5. Nerve growth factor (NGF), produced from the inflammatory site, is responsible for acute and long-term alterations that occur in DRG neurons.

Currently Seeking Students: Yes

Time Commitment: 8 hours per week

Possible Coauthorship: Yes

Compensation: Unpaid

Location: OSU-CHS

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Projects

The role of glutamatergic sensory neurons in the initiation of and response to colitis

Miller, K.

Oklahoma Center for the Advancement of Science and Technology

Project: Research

Research Output

1205 Citations
21 h-Index
50 Article
1 Review article

Separation of rat epidermis and dermis with thermolysin to detect site-specific inflammatory mRNA and protein

Gujar, V., Anderson, M., Miller, K., Pande, R. D., Nawani, P. & Das, S., 2020, (Accepted/In press) In : JoVE.

Research output: Contribution to journal › Article

The Aerobic and Cognitive Exercise Study (ACES) for community-dwelling older adults with or at-risk for mild cognitive impairment (MCI): Neuropsychological, neurobiological and neuroimaging outcomes of a randomized clinical trial

Anderson-Hanley, C., Barcelos, N. M., Zimmerman, E. A., Gillen, R. W., Dunnam, M., Cohen, B. D., Yerokhin, V., Miller, K. E., Hayes, D. J., Arciero, P. J., Maloney, M. & Kramer, A. F., 4 May 2018, In : Frontiers in Aging Neuroscience. 10, MAY, 76.

Research output: Contribution to journal › Article

25 Scopus citations

Evaluation of genetic toxicity of 6-diazo-5-oxo-l-norleucine (DON)

Kulkarni, R. M., Dakoulas, E. W., Miller, K. E. & Terse, P. S., 2 Sep 2017, In : Toxicology Mechanisms and Methods. 27, 7, p. 518-527 10 p.

Research output: Contribution to journal › Article

Characterization of glutamatergic neurons in the rat atrial intrinsic cardiac ganglia that project to the cardiac ventricular wall

Wang, T. & Miller, K. E., 4 Aug 2016, In : Neuroscience. 329, p. 134-150 17 p.

Research output: Contribution to journal › Article

2 Scopus citations

Kenneth Miller, PhD

Research Interests