My research interests include Metalloproteases (mainly ADAMTS family) that are involved in the pathogenesis of cardiovascular disease, ADAMTS13 testing in Thrombotic Thrombocytopenia Purpura (TTP) and the role of von Willebrand factor (VWF) in thrombotic/bleeding disorders. I am also interested in developing and optimizing fluorogenic substrates for enzymes of clinical significance.

Research Opportunities with Dr. Muia

Research Area: Biochemistry, Cardiovascular Biology, Thrombosis, Hemostasis

Project Title: Metalloproteases in Cardiovascular and Inflammatory Diseases

Project Description: My research interests are in the study of enzymes called ADAMTS (short for a disintegrin and metalloproteinase with thrombospondin motifs) metalloproteases. ADAMTS is a family of 19 secreted, multidomain, metalloproteases involved in tissue morphogenesis, hemostasis, inflammation, bone development, and extracellular matrix remodeling. Apart from their biological functions, ADAMTS metalloproteases have been implicated in acquired and genetic disorders in humans. Despite the critical roles these proteases play in the biological system, knowledge about their molecular structures, regulation, biological pathways, and biochemical mode-of-action mechanisms is severely limited. My current focus is on the ADAMTS proteases implicated in cardiovascular and inflammatory diseases.

Currently Seeking Students: Yes

Time Commitment: Flexible

Possible Coauthorship: Yes

Compensation: Unpaid

Location: OSU-CHS