• 141 Citations
  • 5 h-Index
20082020

Research output per year

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Personal profile

Research interests

My research interests include Metalloproteases (mainly ADAMTS family) that are involved in the pathogenesis of cardiovascular disease, ADAMTS13 testing in Thrombotic Thrombocytopenia Purpura (TTP) and the role of von Willebrand factor (VWF) in thrombotic/bleeding disorders. I am also interested in developing and optimizing fluorogenic substrates for enzymes of clinical significance.

Research Opportunities with Dr. Muia

Research Area: Biochemistry, Cardiovascular Biology, Thrombosis, Hemostasis

Project Title: Metalloproteases in Cardiovascular and Inflammatory Diseases

Project Description: My research interests are in the study of enzymes called ADAMTS (short for a disintegrin and metalloproteinase with thrombospondin motifs) metalloproteases. ADAMTS is a family of 19 secreted, multidomain, metalloproteases involved in tissue morphogenesis, hemostasis, inflammation, bone development, and extracellular matrix remodeling. Apart from their biological functions, ADAMTS metalloproteases have been implicated in acquired and genetic disorders in humans. Despite the critical roles these proteases play in the biological system, knowledge about their molecular structures, regulation, biological pathways, and biochemical mode-of-action mechanisms is severely limited. My current focus is on the ADAMTS proteases implicated in cardiovascular and inflammatory diseases.

Currently Seeking Students: Yes

Time Commitment: Flexible

Possible Coauthorship: Yes

Compensation: Unpaid

Location: OSU-CHS

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Research Output

  • 141 Citations
  • 5 h-Index
  • 6 Article
  • 2 Letter
  • 1 Review article

International Council for Standardization in Haematology (ICSH) recommendations for laboratory measurement of ADAMTS13

Mackie, I., Mancini, I., Muia, J., Kremer Hovinga, J., Nair, S., Machin, S. & Baker, R., 2020, (Accepted/In press) In : International Journal of Laboratory Hematology.

Research output: Contribution to journalReview article

Open Access
  • Adjuvant low-dose rituximab and plasma exchange for acquired TTP

    behalf of the ART Investigators, 26 Sep 2019, In : Blood. 134, 13, p. 1106-1109 4 p.

    Research output: Contribution to journalLetter

    5 Scopus citations

    Exploring the "minimal" structure of a functional ADAMTS13 by mutagenesis and small-angle X-ray scattering

    Zhu, J., Muia, J., Gupta, G., Westfield, L. A., Vanhoorelbeke, K., Tolia, N. H. & Sadler, J. E., 25 Apr 2019, In : Blood. 133, 17, p. 1909-1918 10 p.

    Research output: Contribution to journalArticle

  • 5 Scopus citations

    Phylogenetic and functional analysis of ADAMTS13 identifies highly conserved domains essential for allosteric regulation

    Muia, J., Zhu, J., Greco, S. C., Vanhoorelbeke, K., Gupta, G., Westfield, L. A. & Evan Sadler, J., 25 Apr 2019, In : Blood. 133, 17, p. 1899-1908 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • 7 Scopus citations

    Reflections on scientific collaboration between basic researchers and clinicians

    Muia, J. & Casari, C., 1 Oct 2016, In : Journal of Thrombosis and Haemostasis. 14, 10, p. 1905-1907 3 p.

    Research output: Contribution to journalLetter

    Open Access
  • 1 Scopus citations

    Press / Media