George Huang, PhD

Assistant Professor

  • 477 Citations
  • 14 h-Index
20042020

Research output per year

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Personal profile

Research interests

I am interested in bacterial pathogenesis with particular emphasis on the anaerobic pathogen Clostridium difficile and Fusobacterium nucleatum. C. difficile is the number one cause of antibiotic-associated diarrhea worldwide and is a public health concern due to its economic burden and patient relapses. The usage of inappropraiate antibiotics disrupt the intestinal normal flora, which allows C. difficile to proliferate and damage the gut linings. In our lab we are taking a three-prong approach to combat with C. difficile infection. 1. Prevention via the development of a mucosal vaccine. 2. Offensive measures via screening for non-antibiotic antimicrobial agents. 3. Dissecting the molecular basis of toxin regulation.

On the study of F. nucleatum, we are interested in whether and how it is associated with increase incidence of oral squamous cell carcinoma. Using clinical samples along with molecular genetic tools, we are searching for novel virulence factors that contribute to cancer promotion.

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Research Output

  • 477 Citations
  • 14 h-Index
  • 29 Article
  • 1 Chapter

Micro-colonization of arsenic-resistant Staphylococcus sp. As-3 on arsenopyrite (FeAsS) drives arsenic mobilization under anoxic sub-surface mimicking conditions

Rathod, J., Jean, J. S., Jiang, W. T., Huang, I. H., Liu, B. H. & Lee, Y. C., 15 Jun 2019, In : Science of the Total Environment. 669, p. 527-539 13 p.

Research output: Contribution to journalArticle

  • 4 Scopus citations

    Swimming pool-associated Vittaforma-like microsporidia linked to microsporidial keratoconjunctivitis outbreak, Taiwan

    Chen, J. S., Hsu, T. K., Hsu, B. M., Chao, S. C., Huang, T. Y., Ji, D. D., Yang, P. Y. & Huang, I. H., 1 Jan 2019, In : Emerging Infectious Diseases. 25, 11, p. 2100-2103 4 p.

    Research output: Contribution to journalArticle

    Open Access
  • The Transcriptional Regulator Lrp Contributes to Toxin Expression, Sporulation, and Swimming Motility in Clostridium difficile

    Chen, K. Y., Rathod, J., Chiu, Y. C., Chen, J. W., Tsai, P. J. & Huang, I. H., 1 Jan 2019, In : Frontiers in cellular and infection microbiology. 9, 1 p.

    Research output: Contribution to journalArticle

    Open Access