Research output per year
Research output per year
Personal profile
Research interests
The research focuses on the integration of organic and medicinal chemistry to discover and develop novel therapeutics for pain management and substance use disorders. This work addresses the urgent need for more effective and safer treatments for pain and addiction by leveraging innovative methodologies. Through an interdisciplinary approach, the research aims to identify new compounds with potential therapeutic benefits, targeting pathways involved in pain signaling and addiction. The goal is to develop treatments that offer improved efficacy, reduced side effects, and a lower risk of dependence, ultimately advancing healthcare outcomes.
Education/Academic qualification
PhD, National Taiwan Normal University
1 Sep 2007 → 24 Apr 2014
Award Date: 25 Apr 2014
Master, Swami Ramanand Teerth Marathwada University
1 Jun 1999 → 30 Jun 2001
Award Date: 30 Nov 2001
Keywords
- QD Chemistry
- Synthetic Organic chemistry
- Medicinal Chemistry
- Drug discovery and development
- small molecules
- Structure Activity Relationship
- Asymmetric Synthesis
- Catalysis
- Targeted protein degradation (TPD)
- Proteolysis Targeting Chimeras (PROTACs)
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Collaborations and top research areas from the last five years
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Research output
- 13 Article
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A PKM2 inhibitor induces apoptosis and autophagy through JAK2 in human oral squamous cell carcinoma cells
Weng, J. R., Gopula, B., Chu, P. C., Hu, J. L. & Feng, C. H., 1 Aug 2023, In: Chemico-Biological Interactions. 380, 110538.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Asymmetric Synthesis of β-Aryl β-Imido Sulfones Using Rhodium Catalysts with Chiral Diene Ligands: Synthesis of Apremilast
Syu, J. F., Gopula, B., Jian, J. H., Li, W. S., Kuo, T. S., Wu, P. Y., Henschke, J. P., Hsieh, M. C., Tsai, M. K. & Wu, H. L., 21 Jun 2019, In: Organic Letters. 21, 12, p. 4614-4618 5 p.Research output: Contribution to journal › Article › peer-review
20 Scopus citations -
Development of Novel Irreversible Pyruvate Kinase M2 Inhibitors
Hsieh, I. S., Gopula, B., Chou, C. C., Wu, H. Y., Chang, G. D., Wu, W. J., Chang, C. S., Chu, P. C. & Chen, C. S., 26 Sep 2019, In: Journal of Medicinal Chemistry. 62, 18, p. 8497-8510 14 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
A Rapid Synthesis of Chiral Allylic Amines via Microwave-assisted Asymmetric Alkenylation of N-Tosyl Aldimines Catalyzed by Rhodium/Chiral Diene Complexes
Gopula, B., Zeng, H. W., Wu, P. Y., Henschke, J. P. & Wu, H. L., Mar 2018, In: Journal of the Chinese Chemical Society. 65, 3, p. 312-316 5 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Novel AR-12 derivatives, P12-23 and P12-34, inhibit flavivirus replication by blocking host de novo pyrimidine biosynthesis
Yang, C. F., Gopula, B., Liang, J. J., Li, J. K., Chen, S. Y., Lee, Y. L., Chen, C. S. & Lin, Y. L., 1 Dec 2018, In: Emerging Microbes and Infections. 7, 1, 187.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations